67398-11-2Relevant articles and documents
Amidoalkylation of phosphorus trichloride with acetamide and functionalized cyclic ketones-evidence of dominating role of side-reactions
Dziuganowska, Zofia A.,Andrasiak, Iga,lepokura, Katarzyna,Kafarski, Pawel
, p. 1068 - 1075 (2014/11/07)
The course of the reaction between phosphorus trichloride, acetamide and ethyl oxoalkanecarboxylates was studied in terms of the production of side-products. When ethyl 2-oxocycloalkane-and 4-oxocyclohexanecarboxylates were used as substrates, not only mi
Amidoalkylation of phosphorus trichloride with acetamide and alkyl oxocycloalkanecarboxylates
Ziora, Zyta,Kafarski, PaweL
experimental part, p. 1047 - 1053 (2009/12/03)
The course of the reaction between phosphorus trichloride, acetamide, and ethyl oxoalkanecarboxylates was studied in terms of the production of side-products. When alkyl 2-oxocycloalkanecarboxylates were used as substrates, together with the expected prod
The Synthesis of 1-Aminoalkylphosphonic Acids. A Revised Mechanism of the Reaction of Phosphorus Trichloride, Amides and Aldehydes or Ketones in Acetic Acid (Oleksyszyn Reaction)
Soroka, Miroslaw
, p. 331 - 334 (2007/10/02)
The mechanism of the amidoalkylation of trivalent phosphorus compounds in acetic acid has been reinvestigated.Evidence is presented that 1-(acylamino)alkyl acetates 5 and not N,N'-alkylidenebisamides 2 are the intermediates in this reaction.Supporting literature analogies are discussed.This paper also describes a convenient procedure for the preparation of crude (acylamino)alkyl alkanoates 5, which are excellent amidoalkylating agents.The usefulness of these reagents is demonstrated by a simple two-step "one pot" synthesis of 1-aminoalkylphosphinic acids 1.
