tert-Butyl-((S)-2-{(4R,6R)-6-[(4S,6S)-6-((R)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-propoxy)-dimethyl-silane

Base Information

Chemical Name:tert-Butyl-((S)-2-{(4R,6R)-6-[(4S,6S)-6-((R)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-propoxy)-dimethyl-silane
CAS No.:144402-37-9
Molecular Formula:C₃₈H₅₈O₇Si
Molecular Weight:654.96
Hs Code.:

tert-Butyl-((S)-2-{(4R,6R)-6-[(4S,6S)-6-((R)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-propoxy)-dimethyl-silane

Synonyms:tert-Butyl-((S)-2-{(4R,6R)-6-[(4S,6S)-6-((R)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-propoxy)-dimethyl-silane

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Chemical Property of tert-Butyl-((S)-2-{(4R,6R)-6-[(4S,6S)-6-((R)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-propoxy)-dimethyl-silane

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Technology Process of tert-Butyl-((S)-2-{(4R,6R)-6-[(4S,6S)-6-((R)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-propoxy)-dimethyl-silane

There total 27 articles about tert-Butyl-((S)-2-{(4R,6R)-6-[(4S,6S)-6-((R)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-propoxy)-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 144402-36-8
(2R,4R,6S,8R,10R,11S)-12-<(tert-butyldimethylsilyl)oxy>-1,2-O-diphenylmethylidene-8,10-O-isopropylidene-11-methyldodecane-1,2,4,6,8,10-hexol

: 77-76-9
2,2-dimethoxy-propane

: 144402-37-9
(2R,4R,6S,8R,10R,11S)-12-<(tert-butyldimethylsilyl)oxy>-1,2-O-diphenylmethylidene-4,6:8,10-bis-O-isopropylidene-11-methyldodecane-1,2,4,6,8,10-hexol

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; for 0.666667h;
DOI:10.3987/COM-92-6041

Reference yield: 100.0%

: 144402-36-8
(2S,4R)-1-{(4R,6R)-6-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-5-((R)-2,2-diphenyl-[1,3]dioxolan-4-yl)-pentane-2,4-diol

: 77-76-9
2,2-dimethoxy-propane

: 144402-37-9
tert-Butyl-((S)-2-{(4R,6R)-6-[(4S,6S)-6-((R)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-propoxy)-dimethyl-silane

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; for 0.666667h;
DOI:10.3987/COM-92-6041

Reference yield:

: 81380-10-1
(2S,3S)-4-benzyloxy-1,2-epoxy-3-methylbutane

: 144402-37-9
tert-Butyl-((S)-2-{(4R,6R)-6-[(4S,6S)-6-((R)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-propoxy)-dimethyl-silane

Guidance literature:: Multi-step reaction with 13 steps

1: 1.) n-BuLi / 1.) THF, -30 deg C, 2 h, 2.) THF, -25 deg C, 15 h

2: 88 percent / MeI, CaCO₃, H₂O / acetonitrile / 16 h

3: 95 percent / NaBH₄, Et₂BOMe / tetrahydrofuran; methanol / 3 h / -78 °C

4: 90 percent / PPTS / CH₂Cl₂ / 0.33 h

5: 81 percent / H₂ / Pd(OH)2/C / ethyl acetate / 0.5 h

6: 99 percent / imidazole / dimethylformamide / 3.5 h

7: 81 percent / Li, NH₃ (liq.) / tetrahydrofuran; propan-2-ol / 0.25 h / -70 °C

8: Py / 2.5 h / 0 °C

9: t-BuOK / diethyl ether; methanol / 1.5 h

10: 1.) n-BuLi / 1.) THF, -30 deg C, 2 h, 2.) THF, -25 deg C, 15 h

11: 68 percent / MeI, CaCO₃, H₂O / acetonitrile / 16 h

12: Me₄NBH(OAc)3, AcOH / acetonitrile / 20 h / -25 °C

13: 100 percent / PPTS / CH₂Cl₂ / 0.67 h

With pyridine; 1H-imidazole; sodium tetrahydroborate; n-butyllithium; diethyl methoxy borane; potassium tert-butylate; ammonia; water; hydrogen; pyridinium p-toluenesulfonate; lithium; acetic acid; calcium carbonate; tetramethylammonium triacetoxyborohydride; methyl iodide; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.3987/COM-92-6041