3-(2,4-dimethyl-3-vinyl-phenyl)-2,2-dimethyl-propionic acid methyl ester

Base Information

Chemical Name:3-(2,4-dimethyl-3-vinyl-phenyl)-2,2-dimethyl-propionic acid methyl ester
CAS No.:820965-01-3
Molecular Formula:C₁₆H₂₂O₂
Molecular Weight:246.349
Hs Code.:

Synonyms:3-(2,4-dimethyl-3-vinyl-phenyl)-2,2-dimethyl-propionic acid methyl ester

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Chemical Property of 3-(2,4-dimethyl-3-vinyl-phenyl)-2,2-dimethyl-propionic acid methyl ester

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Technology Process of 3-(2,4-dimethyl-3-vinyl-phenyl)-2,2-dimethyl-propionic acid methyl ester

There total 2 articles about 3-(2,4-dimethyl-3-vinyl-phenyl)-2,2-dimethyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 74-88-4
methyl iodide

: 820965-00-2
2-(2,4-dimethyl-3-vinyl-benzyl)-acrylic acid methyl ester

: 820965-01-3
3-(2,4-dimethyl-3-vinyl-phenyl)-2,2-dimethyl-propionic acid methyl ester

Guidance literature:: 2-(2,4-dimethyl-3-vinyl-benzyl)-acrylic acid methyl ester; With copper(l) iodide; methyllithium; diisobutylaluminium hydride; N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; diethyl ether; hexane; at -50 - -10 ℃; for 1h;

methyl iodide; In tetrahydrofuran; diethyl ether; hexane; at -10 ℃; for 25h;
DOI:10.1021/ja044429s

Reference yield:

: 820964-83-8
2,6-dimethyl-3-(tributylstannyl)styrene

: 820965-01-3
3-(2,4-dimethyl-3-vinyl-phenyl)-2,2-dimethyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 87 percent / Pd₂(dba)3; PPh₃ / 1-methyl-pyrrolidin-2-one / 3 h / 100 °C

2.1: CuI; MeLi; DIBAL-H / HMPA / tetrahydrofuran; diethyl ether; hexane / 1 h / -50 - -10 °C

2.2: 99 percent / tetrahydrofuran; diethyl ether; hexane / 25 h / -10 °C

With copper(l) iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; methyllithium; diisobutylaluminium hydride; triphenylphosphine; N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; hexane;
DOI:10.1021/ja044429s

Reference yield: 79.0%

: 820965-01-3
3-(2,4-dimethyl-3-vinyl-phenyl)-2,2-dimethyl-propionic acid methyl ester

: 820965-02-4
3-[3-(2-hydroxy-ethyl)-2,4-dimethyl-phenyl]-2,2-dimethyl-propionic acid methyl ester

Guidance literature:: 3-(2,4-dimethyl-3-vinyl-phenyl)-2,2-dimethyl-propionic acid methyl ester; With Thexylboran; In tetrahydrofuran; at 0 ℃; for 3h;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/ja044429s