Benzenepropanoic acid, 3-ethenyl-2,4-dimethyl-alpha-methylene-, methyl ester (9CI)

Base Information

Chemical Name:Benzenepropanoic acid, 3-ethenyl-2,4-dimethyl-alpha-methylene-, methyl ester (9CI)
CAS No.:820965-00-2
Molecular Formula:C15H18 O2
Molecular Weight:230.307
Hs Code.:
Mol file:820965-00-2.mol

Synonyms:Benzenepropanoic acid, 3-ethenyl-2,4-dimethyl-alpha-methylene-, methyl ester (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzenepropanoic acid, 3-ethenyl-2,4-dimethyl-alpha-methylene-, methyl ester (9CI)

Chemical Property:

PSA：26.30000
LogP:3.21810

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of Benzenepropanoic acid, 3-ethenyl-2,4-dimethyl-alpha-methylene-, methyl ester (9CI)

There total 1 articles about Benzenepropanoic acid, 3-ethenyl-2,4-dimethyl-alpha-methylene-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 4224-69-5
methyl 2-(bromomethyl)propenoate

: 820964-83-8
2,6-dimethyl-3-(tributylstannyl)styrene

: 820965-00-2
2-(2,4-dimethyl-3-vinyl-benzyl)-acrylic acid methyl ester

Guidance literature:: With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; triphenylphosphine; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 3h;
DOI:10.1021/ja044429s

Reference yield: 99.0%

: 74-88-4
methyl iodide

: 820965-00-2
2-(2,4-dimethyl-3-vinyl-benzyl)-acrylic acid methyl ester

: 820965-01-3
3-(2,4-dimethyl-3-vinyl-phenyl)-2,2-dimethyl-propionic acid methyl ester

Guidance literature:: 2-(2,4-dimethyl-3-vinyl-benzyl)-acrylic acid methyl ester; With copper(l) iodide; methyllithium; diisobutylaluminium hydride; N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; diethyl ether; hexane; at -50 - -10 ℃; for 1h;

methyl iodide; In tetrahydrofuran; diethyl ether; hexane; at -10 ℃; for 25h;
DOI:10.1021/ja044429s

Reference yield:

: 820965-00-2
2-(2,4-dimethyl-3-vinyl-benzyl)-acrylic acid methyl ester

: 820965-02-4
3-[3-(2-hydroxy-ethyl)-2,4-dimethyl-phenyl]-2,2-dimethyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuI; MeLi; DIBAL-H / HMPA / tetrahydrofuran; diethyl ether; hexane / 1 h / -50 - -10 °C

1.2: 99 percent / tetrahydrofuran; diethyl ether; hexane / 25 h / -10 °C

2.1: Me₂CHCMe₂BH₂ / tetrahydrofuran / 3 h / 0 °C

2.2: 79 percent / NaOH; aq. H₂O₂ / tetrahydrofuran / 3 h / 20 °C

With copper(l) iodide; Thexylboran; methyllithium; diisobutylaluminium hydride; N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/ja044429s