N¹-butyl-N²-(2-fluorophenyl)-N²-methyl-N¹-(2-nitrophenyl)benzene-1,2-diamine

Base Information

Chemical Name:N¹-butyl-N²-(2-fluorophenyl)-N²-methyl-N¹-(2-nitrophenyl)benzene-1,2-diamine
CAS No.:1429049-08-0
Molecular Formula:C₂₃H₂₄FN₃O₂
Molecular Weight:393.461
Hs Code.:

N<SUP>1</SUP>-butyl-N<SUP>2</SUP>-(2-fluorophenyl)-N<SUP>2</SUP>-methyl-N<SUP>1</SUP>-(2-nitrophenyl)benzene-1,2-diamine

Synonyms:N¹-butyl-N²-(2-fluorophenyl)-N²-methyl-N¹-(2-nitrophenyl)benzene-1,2-diamine

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Chemical Property of N¹-butyl-N²-(2-fluorophenyl)-N²-methyl-N¹-(2-nitrophenyl)benzene-1,2-diamine

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Technology Process of N¹-butyl-N²-(2-fluorophenyl)-N²-methyl-N¹-(2-nitrophenyl)benzene-1,2-diamine

There total 6 articles about N¹-butyl-N²-(2-fluorophenyl)-N²-methyl-N¹-(2-nitrophenyl)benzene-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 109-65-9
1-bromo-butane

: 1429049-03-5
N¹-(2-fluorophenyl)-N¹-methyl-N²-(2-nitrophenyl)benzene-1,2-diamine

: 1429049-08-0
N¹-butyl-N²-(2-fluorophenyl)-N²-methyl-N¹-(2-nitrophenyl)benzene-1,2-diamine

Guidance literature:: N¹-(2-fluorophenyl)-N¹-methyl-N²-(2-nitrophenyl)benzene-1,2-diamine; With potassium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

1-bromo-butane; In N,N-dimethyl-formamide; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jo302795w

Reference yield:

: 28898-02-4
N-(2-Fluorophenyl)-2-nitrobenzeneamine

: 1429049-08-0
N¹-butyl-N²-(2-fluorophenyl)-N²-methyl-N¹-(2-nitrophenyl)benzene-1,2-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / acetone / 1 h / Inert atmosphere; Reflux

2.1: copper(l) chloride; potassium borohydride / methanol / 2 h / 20 °C / Inert atmosphere

3.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 24 h / 130 °C / Inert atmosphere; Sealed tube

4.1: potassium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

4.2: 3 h / 80 °C / Inert atmosphere

With potassium borohydride; potassium hydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; copper(l) chloride; potassium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In methanol; N,N-dimethyl-formamide; acetone; toluene; 3.1: |Buchwald-Hartwig Coupling;
DOI:10.1021/jo302795w

Reference yield:

: 908242-57-9
N-(2-fluorophenyl)-N-methyl-2-nitroaniline

: 1429049-08-0
N¹-butyl-N²-(2-fluorophenyl)-N²-methyl-N¹-(2-nitrophenyl)benzene-1,2-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) chloride; potassium borohydride / methanol / 2 h / 20 °C / Inert atmosphere

2.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 24 h / 130 °C / Inert atmosphere; Sealed tube

3.1: potassium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

3.2: 3 h / 80 °C / Inert atmosphere

With potassium borohydride; potassium hydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; copper(l) chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In methanol; N,N-dimethyl-formamide; toluene; 2.1: |Buchwald-Hartwig Coupling;
DOI:10.1021/jo302795w