11-(4-Methoxy-phenyl)-1,3-dimethyl-10,11-dihydro-1H,6aH-6-oxa-9-thia-1,3,5,11-tetraaza-pentaleno[1,6a-a]naphthalene-2,4-dione

Base Information

• Chemical Name: 11-(4-Methoxy-phenyl)-1,3-dimethyl-10,11-dihydro-1H,6aH-6-oxa-9-thia-1,3,5,11-tetraaza-pentaleno[1,6a-a]naphthalene-2,4-dione
• CAS No.: 116316-95-1
• Molecular Formula: C₁₉H₁₈N₄O₄S
• Molecular Weight: 398.442
• Mol file: 116316-95-1.mol

Synonyms:11-(4-Methoxy-phenyl)-1,3-dimethyl-10,11-dihydro-1H,6aH-6-oxa-9-thia-1,3,5,11-tetraaza-pentaleno[1,6a-a]naphthalene-2,4-dione

Chemical Property of 11-(4-Methoxy-phenyl)-1,3-dimethyl-10,11-dihydro-1H,6aH-6-oxa-9-thia-1,3,5,11-tetraaza-pentaleno[1,6a-a]naphthalene-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-(4-Methoxy-phenyl)-1,3-dimethyl-10,11-dihydro-1H,6aH-6-oxa-9-thia-1,3,5,11-tetraaza-pentaleno[1,6a-a]naphthalene-2,4-dione

There total 3 articles about 11-(4-Methoxy-phenyl)-1,3-dimethyl-10,11-dihydro-1H,6aH-6-oxa-9-thia-1,3,5,11-tetraaza-pentaleno[1,6a-a]naphthalene-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde oxime (116316-90-6) → 11-(4-Methoxy-phenyl)-1,3-dimethyl-10,11-dihydro-1H,6aH-6-oxa-9-thia-1,3,5,11-tetraaza-pentaleno[1,6a-a]naphthalene-2,4-dione (116316-95-1)

Guidance literature:

With sodium hypochlorite; triethylamine; In dichloromethane; at 0 - 10 ℃; for 3h;

DOI:10.1055/s-1988-27568

Reference yield:

6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde (116360-55-5) → 11-(4-Methoxy-phenyl)-1,3-dimethyl-10,11-dihydro-1H,6aH-6-oxa-9-thia-1,3,5,11-tetraaza-pentaleno[1,6a-a]naphthalene-2,4-dione (116316-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / NH₂OH*HCl, aq. NaOH / ethanol / 4 h / Ambient temperature

2: 75 percent / Et₃N, 10percent aq. NaOCl / CH₂Cl₂ / 3 h / 0 - 10 °C

With sodium hydroxide; sodium hypochlorite; hydroxylamine hydrochloride; triethylamine; In ethanol; dichloromethane;

DOI:10.1055/s-1988-27568

Reference yield:

6-chloro-5-formyl-1,3-dimethyluracil (35824-85-2) → 11-(4-Methoxy-phenyl)-1,3-dimethyl-10,11-dihydro-1H,6aH-6-oxa-9-thia-1,3,5,11-tetraaza-pentaleno[1,6a-a]naphthalene-2,4-dione (116316-95-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

2: 61 percent / NH₂OH*HCl, aq. NaOH / ethanol / 4 h / Ambient temperature

3: 75 percent / Et₃N, 10percent aq. NaOCl / CH₂Cl₂ / 3 h / 0 - 10 °C

With sodium hydroxide; sodium hypochlorite; hydroxylamine hydrochloride; triethylamine; In ethanol; dichloromethane;

DOI:10.1055/s-1988-27568

upstream raw materials:

6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde oxime

6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

6-chloro-5-formyl-1,3-dimethyluracil