6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde oxime

Base Information

• Chemical Name: 6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde oxime
• CAS No.: 116316-90-6
• Molecular Formula: C₁₉H₂₀N₄O₄S
• Molecular Weight: 400.458

Synonyms:6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde oxime

Chemical Property of 6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde oxime

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Technology Process of 6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde oxime

There total 2 articles about 6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde (116360-55-5) → 6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde oxime (116316-90-6)

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; In ethanol; for 4h; Ambient temperature;

DOI:10.1055/s-1988-27568

Reference yield:

6-chloro-5-formyl-1,3-dimethyluracil (35824-85-2) → 6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde oxime (116316-90-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

2: 61 percent / NH₂OH*HCl, aq. NaOH / ethanol / 4 h / Ambient temperature

With sodium hydroxide; hydroxylamine hydrochloride; triethylamine; In ethanol; dichloromethane;

DOI:10.1055/s-1988-27568

Reference yield: 75.0%

6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde oxime (116316-90-6) → 11-(4-Methoxy-phenyl)-1,3-dimethyl-10,11-dihydro-1H,6aH-6-oxa-9-thia-1,3,5,11-tetraaza-pentaleno[1,6a-a]naphthalene-2,4-dione (116316-95-1)

Guidance literature:

With sodium hypochlorite; triethylamine; In dichloromethane; at 0 - 10 ℃; for 3h;

DOI:10.1055/s-1988-27568

upstream raw materials:

6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

6-chloro-5-formyl-1,3-dimethyluracil

Downstream raw materials:

11-(4-Methoxy-phenyl)-1,3-dimethyl-10,11-dihydro-1H,6aH-6-oxa-9-thia-1,3,5,11-tetraaza-pentaleno[1,6a-a]naphthalene-2,4-dione

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