2-(1-benzyl-2-oxo-1,2-dihydro-quinoxalin-6-yl)-1-butyl-1H-benzoimidazole-5-carboxylic acid methyl ester

Base Information

• Chemical Name: 2-(1-benzyl-2-oxo-1,2-dihydro-quinoxalin-6-yl)-1-butyl-1H-benzoimidazole-5-carboxylic acid methyl ester
• CAS No.: 1283741-72-9
• Molecular Formula: C₂₈H₂₆N₄O₃
• Molecular Weight: 466.539
• Mol file: 1283741-72-9.mol

Synonyms:2-(1-benzyl-2-oxo-1,2-dihydro-quinoxalin-6-yl)-1-butyl-1H-benzoimidazole-5-carboxylic acid methyl ester

Chemical Property of 2-(1-benzyl-2-oxo-1,2-dihydro-quinoxalin-6-yl)-1-butyl-1H-benzoimidazole-5-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-benzyl-2-oxo-1,2-dihydro-quinoxalin-6-yl)-1-butyl-1H-benzoimidazole-5-carboxylic acid methyl ester

There total 3 articles about 2-(1-benzyl-2-oxo-1,2-dihydro-quinoxalin-6-yl)-1-butyl-1H-benzoimidazole-5-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 3-nitro-4-fluorobenzoic acid (453-71-4) + chloroacetyl chloride (79-04-9) + benzylamine (100-46-9) → 2-(1-benzyl-2-oxo-1,2-dihydro-quinoxalin-6-yl)-1-butyl-1H-benzoimidazole-5-carboxylic acid methyl ester (1283741-72-9) + C28H28N4O3 (1332362-55-6)

Guidance literature:

3-nitro-4-fluorobenzoic acid; poly(ethylene glycol) α,ω-bis[3-amino-4-(butylamino)benzoate]; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 0.333333h; Inert atmosphere; Microwave irradiation;

With magnesium sulfate; trifluoroacetic acid; In 1,2-dichloro-ethane; for 0.5h; Inert atmosphere; Microwave irradiation;

methanol; chloroacetyl chloride; benzylamine; regioselective reaction; Further stages;

DOI:10.1016/j.tet.2011.01.040

Reference yield:

C28H28N4O3 (1332362-55-6) → 2-(1-benzyl-2-oxo-1,2-dihydro-quinoxalin-6-yl)-1-butyl-1H-benzoimidazole-5-carboxylic acid methyl ester (1283741-72-9)

Guidance literature:

With air;

DOI:10.1016/j.tet.2011.01.040

Reference yield:

3-nitro-4-fluorobenzoic acid (453-71-4) + benzylamine (100-46-9) → 2-(1-benzyl-2-oxo-1,2-dihydro-quinoxalin-6-yl)-1-butyl-1H-benzoimidazole-5-carboxylic acid methyl ester (1283741-72-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0.33 h / Inert atmosphere; Microwave irradiation

1.2: 0.5 h / Inert atmosphere; Microwave irradiation

2.1: air

With dmap; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/j.tet.2011.01.040

upstream raw materials:

methanol

3-nitro-4-fluorobenzoic acid

chloroacetyl chloride

benzylamine