4-(4-fluoro-benzoyl)-1H-pyrrole-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-(4-fluoro-benzoyl)-1H-pyrrole-2-carboxylic acid ethyl ester
• CAS No.: 935859-53-3
• Molecular Formula: C₁₄H₁₂FNO₃
• Molecular Weight: 261.253
• Mol file: 935859-53-3.mol

Synonyms:4-(4-fluoro-benzoyl)-1H-pyrrole-2-carboxylic acid ethyl ester

Chemical Property of 4-(4-fluoro-benzoyl)-1H-pyrrole-2-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-(4-fluoro-benzoyl)-1H-pyrrole-2-carboxylic acid ethyl ester

There total 1 articles about 4-(4-fluoro-benzoyl)-1H-pyrrole-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

ethyl 1H-pyrrole-2-carboxylate (2199-43-1) + 4-fluorobenzoyl chloride (403-43-0) → 4-(4-fluoro-benzoyl)-1H-pyrrole-2-carboxylic acid ethyl ester (935859-53-3)

Guidance literature:

With aluminium trichloride; In 1,2-dichloro-ethane; at -20 ℃;

DOI:10.1016/j.bmcl.2006.10.096

Reference yield: 58.0%

4-(4-fluoro-benzoyl)-1H-pyrrole-2-carboxylic acid ethyl ester (935859-53-3) + ethylene dibromide (106-93-4) → 1-(2-bromo-ethyl)-4-(4-fluoro-benzoyl)-1H-pyrrole-2-carboxylic acid ethyl ester (929017-86-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 65 ℃;

DOI:10.1016/j.bmcl.2006.10.096

Reference yield:

4-(4-fluoro-benzoyl)-1H-pyrrole-2-carboxylic acid ethyl ester (935859-53-3) → 7-(4-fluoro-benzyl)-2-[2-(4-piperidin-1-ylmethyl-phenyl)-ethyl]-3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one

Guidance literature:

Multi-step reaction with 3 steps

1: 58 percent / NaH / dimethylformamide / 65 °C

2: 51 percent / NaH / acetonitrile / 80 °C

3: 82 percent / triethylsilane; trifluoroacetic acid / 20 °C

With triethylsilane; sodium hydride; trifluoroacetic acid; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2006.10.096

upstream raw materials:

ethyl 1H-pyrrole-2-carboxylate

4-fluorobenzoyl chloride

Downstream raw materials:

1-(2-bromo-ethyl)-4-(4-fluoro-benzoyl)-1H-pyrrole-2-carboxylic acid ethyl ester

7-(4-fluoro-benzoyl)-2-[2-(4-piperidin-1-ylmethyl-phenyl)-ethyl]-3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one