tert-butyl {5-[(1E)-3-oxo-3-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}amino)prop-1-en-1-yl]-2,3-dihydro-1H-inden-1-yl}carbamate

Base Information

Chemical Name:tert-butyl {5-[(1E)-3-oxo-3-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}amino)prop-1-en-1-yl]-2,3-dihydro-1H-inden-1-yl}carbamate
CAS No.:1299483-37-6
Molecular Formula:C₂₆H₂₆F₆N₂O₃
Molecular Weight:528.494
Hs Code.:

Synonyms:tert-butyl {5-[(1E)-3-oxo-3-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}amino)prop-1-en-1-yl]-2,3-dihydro-1H-inden-1-yl}carbamate

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Chemical Property of tert-butyl {5-[(1E)-3-oxo-3-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}amino)prop-1-en-1-yl]-2,3-dihydro-1H-inden-1-yl}carbamate

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Technology Process of tert-butyl {5-[(1E)-3-oxo-3-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}amino)prop-1-en-1-yl]-2,3-dihydro-1H-inden-1-yl}carbamate

There total 5 articles about tert-butyl {5-[(1E)-3-oxo-3-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}amino)prop-1-en-1-yl]-2,3-dihydro-1H-inden-1-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 65686-68-2,1213368-14-9,1213841-80-5
2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethanamine

: 1299483-36-5
(E)-3-(1-((tert-butoxycarbonyl)amino)-2,3-dihydro-1H-inden-5-yl)acrylic acid

: 1299483-37-6
tert-butyl {5-[(1E)-3-oxo-3-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}amino)prop-1-en-1-yl]-2,3-dihydro-1H-inden-1-yl}carbamate

Guidance literature:: With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In N,N-dimethyl-formamide; at 50 ℃;

Reference yield:

: 185122-74-1
5-bromo-2,3-dihydro-1H-inden-1-one oxime

: 1299483-37-6
tert-butyl {5-[(1E)-3-oxo-3-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}amino)prop-1-en-1-yl]-2,3-dihydro-1H-inden-1-yl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / water; tetrahydrofuran / 0 °C

2: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / 5 h / 150 °C

3: sodium hydroxide / 1 h / Reflux

4: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide / 50 °C

With triethylamine; tris-(o-tolyl)phosphine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium hydroxide; palladium diacetate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 903555-95-3
(±)-tert-butyl (5-bromo-2,3-dihydro-1H-inden-1-yl)carbamate

: 1299483-37-6
tert-butyl {5-[(1E)-3-oxo-3-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}amino)prop-1-en-1-yl]-2,3-dihydro-1H-inden-1-yl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / 5 h / 150 °C

2: sodium hydroxide / 1 h / Reflux

3: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide / 50 °C

With triethylamine; tris-(o-tolyl)phosphine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium hydroxide; palladium diacetate; In N,N-dimethyl-formamide;