ethyl 1-{6-[4'-(benzyloxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Chemical Name:ethyl 1-{6-[4'-(benzyloxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
CAS No.:1374341-98-6
Molecular Formula:C₃₂H₂₅ClF₃N₃O₃
Molecular Weight:592.017
Hs Code.:

Synonyms:ethyl 1-{6-[4'-(benzyloxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Chemical Property of ethyl 1-{6-[4'-(benzyloxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Technology Process of ethyl 1-{6-[4'-(benzyloxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

There total 5 articles about ethyl 1-{6-[4'-(benzyloxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374341-97-5
ethyl 1-[6-(5-chloro-2-{[(trifluoromethyl)sulfonyl]oxy}phenyl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 338454-30-1
[4-(benzyloxy)-3-methylphenyl]boronic acid

: 1374341-98-6
ethyl 1-{6-[4'-(benzyloxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; acetonitrile; at 80 ℃; for 48h; Inert atmosphere;

Reference yield:

: 571-55-1
ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate

: 1374341-98-6
ethyl 1-{6-[4'-(benzyloxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / acetonitrile / 0.83 h / 60 °C

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 3 h / 70 °C / Inert atmosphere

3: benzyltrimethylazanium tetrachloro-λ³-iodanuide / dichloromethane / 24 h / 20 °C

4: pyridine / dichloromethane / 0.42 h / 0 - 20 °C

5: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 48 h / 80 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; benzyltrimethylazanium tetrachloro-λ³-iodanuide; triethylamine; In dichloromethane; water; acetonitrile;

Reference yield:

: 1128268-02-9
ethyl 1-[6-(2-hydroxylphenyl)pyridine-2-yl]-5-trifluoromethyl-1H-pyrazole-4-carboxylate

: 1374341-98-6
ethyl 1-{6-[4'-(benzyloxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: benzyltrimethylazanium tetrachloro-λ³-iodanuide / dichloromethane / 24 h / 20 °C

2: pyridine / dichloromethane / 0.42 h / 0 - 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 48 h / 80 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; benzyltrimethylazanium tetrachloro-λ³-iodanuide; In dichloromethane; water; acetonitrile;