3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)phthalonitrile

Base Information

Chemical Name:3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)phthalonitrile
CAS No.:1352609-30-3
Molecular Formula:C₂₄H₁₇N₉
Molecular Weight:431.459
Hs Code.:

Synonyms:3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)phthalonitrile

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Chemical Property of 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)phthalonitrile

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Technology Process of 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)phthalonitrile

There total 6 articles about 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)phthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₁₅N₉

: 1352609-30-3
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)phthalonitrile

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 356560-84-4
1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione

: 1352609-30-3
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)phthalonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium acetate / methanol; tert-butyl methyl ether; water / 4 h / 20 °C

2: hydrogenchloride / water / 4 h / 70 °C

3: acetic acid / 1,2-dichloro-ethane / 2 h / 120 °C / Inert atmosphere; Sealed tube

4: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; ammonium acetate; acetic acid; In tetrahydrofuran; methanol; tert-butyl methyl ether; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 1352609-89-2
6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine

: 1352609-30-3
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)phthalonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water / 4 h / 70 °C

2: acetic acid / 1,2-dichloro-ethane / 2 h / 120 °C / Inert atmosphere; Sealed tube

3: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; acetic acid; In tetrahydrofuran; methanol; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.03.022