2,4-rioxo-3,6-diphenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2,4-rioxo-3,6-diphenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester
• CAS No.: 118543-66-1
• Molecular Formula: C₁₉H₁₆N₂O₄
• Molecular Weight: 336.347
• Mol file: 118543-66-1.mol

Synonyms:2,4-rioxo-3,6-diphenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

Chemical Property of 2,4-rioxo-3,6-diphenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-rioxo-3,6-diphenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

There total 6 articles about 2,4-rioxo-3,6-diphenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

bis(trichloromethyl) carbonate (32315-10-9) + phenyl isocyanate (103-71-9) + ethyl bromoacetate (105-36-2) + benzonitrile (100-47-0) → 2,4-rioxo-3,6-diphenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (118543-66-1)

Guidance literature:

ethyl bromoacetate; benzonitrile; With methanesulfonic acid; zinc; In tetrahydrofuran; for 2.16667h; Reflux;

phenyl isocyanate; With copper diacetate; In tetrahydrofuran; at 40 ℃; for 1h; Reflux;

bis(trichloromethyl) carbonate; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3.5h; chemoselective reaction;

DOI:10.1021/ol401389j

Reference yield: 60.0%

1-[1-Methoxy-1-phenyl-meth-(Z)-ylidene]-3-phenyl-urea (118543-76-3) + diethyl malonate (105-53-3) → 2,4-rioxo-3,6-diphenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (118543-66-1)

Guidance literature:

With ethanol; sodium; for 168h; Heating;

DOI:10.1055/s-1988-27485

Reference yield:

diethyl 2-[amino(phenyl)methylene]malonate (97652-62-5) + phenyl isocyanate (103-71-9) → 2,4-rioxo-3,6-diphenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (118543-66-1)

Guidance literature:

In dichloromethane; at 40 ℃; Inert atmosphere; Sealed tube;

DOI:10.1055/s-0035-1561973

upstream raw materials:

1-[1-Methoxy-1-phenyl-meth-(Z)-ylidene]-3-phenyl-urea

diethyl malonate

phenyl isocyanate

methyl benzimidate