3-(4-fluorophenyl)-2-(2-((tetrahydro-2H-pyran-4-yl)amino)pyridin-4-yl)chromone

Base Information

Chemical Name:3-(4-fluorophenyl)-2-(2-((tetrahydro-2H-pyran-4-yl)amino)pyridin-4-yl)chromone
CAS No.:1338055-86-9
Molecular Formula:C₂₅H₂₁FN₂O₃
Molecular Weight:416.452
Hs Code.:

Synonyms:3-(4-fluorophenyl)-2-(2-((tetrahydro-2H-pyran-4-yl)amino)pyridin-4-yl)chromone

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Chemical Property of 3-(4-fluorophenyl)-2-(2-((tetrahydro-2H-pyran-4-yl)amino)pyridin-4-yl)chromone

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Technology Process of 3-(4-fluorophenyl)-2-(2-((tetrahydro-2H-pyran-4-yl)amino)pyridin-4-yl)chromone

There total 8 articles about 3-(4-fluorophenyl)-2-(2-((tetrahydro-2H-pyran-4-yl)amino)pyridin-4-yl)chromone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 38041-19-9
4-aminotetrahydropyran

: 1338055-80-3
2-(2-chloropyridin-4-yl)-3-(4-fluorophenyl)chromone

: 1338055-86-9
3-(4-fluorophenyl)-2-(2-((tetrahydro-2H-pyran-4-yl)amino)pyridin-4-yl)chromone

Guidance literature:: With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; sodium t-butanolate; In toluene; at 130 ℃; for 1.5h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm200818j

Reference yield:

: 1338055-74-5
1-(2-chloro-4-pyridin-yl)-3-(2-hydroxyphenyl)propane-1,3-dione

: 1338055-86-9
3-(4-fluorophenyl)-2-(2-((tetrahydro-2H-pyran-4-yl)amino)pyridin-4-yl)chromone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / ethanol / 0.25 h / 100 °C / Microwave irradiation

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

2.2: 0.33 h / -78 °C / Inert atmosphere

3.1: palladium diacetate; potassium carbonate / PEG-400 / 1.5 h / 60 °C / Microwave irradiation

4.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; sodium t-butanolate / toluene / 1.5 h / 130 °C / Inert atmosphere; Microwave irradiation

With sulfuric acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; potassium carbonate; sodium t-butanolate; lithium diisopropyl amide; In tetrahydrofuran; PEG-400; ethanol; toluene; 3.1: Suzuki coupling / 4.1: Buchwald-Hartwig amination;
DOI:10.1021/jm200818j

Reference yield:

: 65287-34-5
2-chloropyridine-4-carbonyl chloride

: 1338055-86-9
3-(4-fluorophenyl)-2-(2-((tetrahydro-2H-pyran-4-yl)amino)pyridin-4-yl)chromone

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 0 - 20 °C

2.1: potassium hydroxide / pyridine / 0.25 h / 100 °C / Microwave irradiation

3.1: sulfuric acid / ethanol / 0.25 h / 100 °C / Microwave irradiation

4.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

4.2: 0.33 h / -78 °C / Inert atmosphere

5.1: palladium diacetate; potassium carbonate / PEG-400 / 1.5 h / 60 °C / Microwave irradiation

6.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; sodium t-butanolate / toluene / 1.5 h / 130 °C / Inert atmosphere; Microwave irradiation

With pyridine; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; potassium carbonate; potassium hydroxide; sodium t-butanolate; lithium diisopropyl amide; In tetrahydrofuran; pyridine; PEG-400; ethanol; toluene; 2.1: Baker-Venkataraman transformation / 5.1: Suzuki coupling / 6.1: Buchwald-Hartwig amination;
DOI:10.1021/jm200818j