N¹-(2-dimethylaminoethyl)-5-methoxy-N¹-methyl-N⁴-(4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)benzene-1,2,4-triamine

Base Information

• Chemical Name: N¹-(2-dimethylaminoethyl)-5-methoxy-N¹-methyl-N⁴-(4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)benzene-1,2,4-triamine
• CAS No.: 1421373-21-8
• Molecular Formula: C₂₃H₂₈N₈O
• Molecular Weight: 432.528

Synonyms:N¹-(2-dimethylaminoethyl)-5-methoxy-N¹-methyl-N⁴-(4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)benzene-1,2,4-triamine

Chemical Property of N¹-(2-dimethylaminoethyl)-5-methoxy-N¹-methyl-N⁴-(4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)benzene-1,2,4-triamine

Chemical Property:

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Technology Process of N¹-(2-dimethylaminoethyl)-5-methoxy-N¹-methyl-N⁴-(4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)benzene-1,2,4-triamine

There total 6 articles about N¹-(2-dimethylaminoethyl)-5-methoxy-N¹-methyl-N⁴-(4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)benzene-1,2,4-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N1-2-(dimethylaminoethyl)-N1-methyl-N4-(4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-yl)-5-methoxy-2-nitrobenzene-1,4-diamine (1421373-22-9) → N1-(2-dimethylaminoethyl)-5-methoxy-N1-methyl-N4-(4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)benzene-1,2,4-triamine (1421373-21-8)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; for 1.5h; Reflux;

Reference yield:

4-(pyrazole[1,5-a]pyridin-3-yl)-2-chloropyrimidine → N1-(2-dimethylaminoethyl)-5-methoxy-N1-methyl-N4-(4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)benzene-1,2,4-triamine (1421373-21-8)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / 22 h / 125 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 1.5 h / 85 °C

3: iron; ammonium chloride / water; ethanol / 1.5 h / Reflux

With iron; ammonium chloride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl acetamide; water;

Reference yield:

N-(2-methoxy-4-fluoro-5-nitrophenyl)-4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-amine (1421373-18-3) → N1-(2-dimethylaminoethyl)-5-methoxy-N1-methyl-N4-(4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)benzene-1,2,4-triamine (1421373-21-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 1.5 h / 85 °C

2: iron; ammonium chloride / water; ethanol / 1.5 h / Reflux

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl acetamide; water;

upstream raw materials:

4-fluoro-2-methoxy-5-nitro-phenylamine

N-(2-methoxy-4-fluoro-5-nitrophenyl)-4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-amine

N₁-2-(dimethylaminoethyl)-N₁-methyl-N₄-(4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-yl)-5-methoxy-2-nitrobenzene-1,4-diamine

4-fluoro-2-methoxyaniline

Downstream raw materials:

C₂₆H₃₀N₈O₂

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