4-methoxy-2-phenoxybenzaldehyde

Base Information

• Chemical Name: 4-methoxy-2-phenoxybenzaldehyde
• CAS No.: 1196088-61-5
• Molecular Formula: C₁₄H₁₂O₃
• Molecular Weight: 228.247
• Mol file: 1196088-61-5.mol

Synonyms:4-methoxy-2-phenoxybenzaldehyde

Chemical Property of 4-methoxy-2-phenoxybenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methoxy-2-phenoxybenzaldehyde

There total 2 articles about 4-methoxy-2-phenoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-fluoro-4-methoxy-benzaldehyde (331-64-6) + phenol (108-95-2,27073-41-2) → 4-methoxy-2-phenoxybenzaldehyde (1196088-61-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl acetamide; for 2h; Reflux;

DOI:10.1002/ejoc.200900676

Reference yield:

Diphenyliodonium triflate (66003-76-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) + 4-methoxy-2-(trimethylsilyl)phenyl triflate (556812-41-0) → 5-methoxy-2-(phenoxy)benzaldehyde (934691-76-6) + 4-methoxy-2-phenoxybenzaldehyde (1196088-61-5)

Guidance literature:

N,N-dimethyl-formamide; 4-methoxy-2-(trimethylsilyl)phenyl triflate; With potassium fluoride; at 20 - 60 ℃; for 0.05h; Inert atmosphere; Schlenk technique;

Diphenyliodonium triflate; at 60 ℃; for 3h; Overall yield = 90 %; Overall yield = 30.9 mg; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol503224u

Reference yield: 96.0%

4-methoxy-2-phenoxybenzaldehyde (1196088-61-5) + (methoxymethyl)triphenylphosphonium chloride (4009-98-7) → 2-(benzyloxy)-4-methoxy-1-(2-methoxyvinyl)benzene (1029608-19-2)

Guidance literature:

(methoxymethyl)triphenylphosphonium chloride; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.166667h;

4-methoxy-2-phenoxybenzaldehyde; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1002/anie.201408910

upstream raw materials:

2-fluoro-4-methoxy-benzaldehyde

phenol

Diphenyliodonium triflate

N,N-dimethyl-formamide

Downstream raw materials:

C₂₁H₂₀O₄

C₂₀H₁₈O₃

C₂₀H₁₈O₅S

C₁₄H₁₄O₅S