4-(2-hydroxybenzylidene)-2-phenyl-1-(pyridin-4-ylmethyl)-1H-imidazol-5(4H)-one

Base Information

• Chemical Name: 4-(2-hydroxybenzylidene)-2-phenyl-1-(pyridin-4-ylmethyl)-1H-imidazol-5(4H)-one
• CAS No.: 1373956-87-6
• Molecular Formula: C₂₂H₁₇N₃O₂
• Molecular Weight: 355.396
• Mol file: 1373956-87-6.mol

Synonyms:4-(2-hydroxybenzylidene)-2-phenyl-1-(pyridin-4-ylmethyl)-1H-imidazol-5(4H)-one

Chemical Property of 4-(2-hydroxybenzylidene)-2-phenyl-1-(pyridin-4-ylmethyl)-1H-imidazol-5(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-hydroxybenzylidene)-2-phenyl-1-(pyridin-4-ylmethyl)-1H-imidazol-5(4H)-one

There total 3 articles about 4-(2-hydroxybenzylidene)-2-phenyl-1-(pyridin-4-ylmethyl)-1H-imidazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-(aminomethyl)pyridine (3731-53-1) + 2-phenyl-4-salicyliden-4H-oxazol-5-one (39167-74-3,57427-90-4,137401-65-1) → 4-(2-hydroxybenzylidene)-2-phenyl-1-(pyridin-4-ylmethyl)-1H-imidazol-5(4H)-one (1373956-87-6)

Guidance literature:

With potassium acetate; acetic acid; Heating;

DOI:10.1016/j.bmc.2012.02.037

Reference yield:

Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) → 4-(2-hydroxybenzylidene)-2-phenyl-1-(pyridin-4-ylmethyl)-1H-imidazol-5(4H)-one (1373956-87-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium acetate; acetic anhydride / Heating

2: potassium acetate; acetic acid / Heating

With potassium acetate; acetic anhydride; acetic acid;

DOI:10.1016/j.bmc.2012.02.037

Reference yield:

benzoyl chloride (98-88-4) → 4-(2-hydroxybenzylidene)-2-phenyl-1-(pyridin-4-ylmethyl)-1H-imidazol-5(4H)-one (1373956-87-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide

1.2: Cooling with ice

2.1: potassium acetate; acetic anhydride / Heating

3.1: potassium acetate; acetic acid / Heating

With potassium acetate; acetic anhydride; acetic acid; sodium hydroxide;

DOI:10.1016/j.bmc.2012.02.037

upstream raw materials:

Hippuric Acid

4-(aminomethyl)pyridine

2-phenyl-4-salicyliden-4H-oxazol-5-one

benzoyl chloride