1978-65-0

Basic information

• Product Name: (4-Fluorophenyl)(morpholino)methanone
• Synonyms: (4-Fluorophenyl)(morpholino)methanone;1-(4-Fluorobenzoyl)morpholine;N-(4-Fluorobenzoyl)morpholine;4-(4-Fluorobenzoyl)morpholine;(4-fluorophenyl)-4-morpholinylMethanone
• CAS NO: 1978-65-0
• Molecular Formula: C₁₁H₁₂FNO₂
• Molecular Weight: 209.22
• Product Categories: blocks;Carboxes;FluoroCompounds
• Mol File: 1978-65-0.mol
• Article Data: 37

Chemical Properties

• Boiling Point: 351.9°C at 760 mmHg
• Flash Point: 166.6°C
• Appearance: /
• Density: 1.232
• Vapor Pressure: 3.98E-05mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: 2-8°C
• PKA: -1.52±0.20(Predicted)
• CAS DataBase Reference: (4-Fluorophenyl)(morpholino)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Fluorophenyl)(morpholino)methanone(1978-65-0)
• EPA Substance Registry System: (4-Fluorophenyl)(morpholino)methanone(1978-65-0)

Safety Data

• Hazardous Substances Data: 1978-65-0(Hazardous Substances Data)

Usage

General Description

"(4-Fluorophenyl)(morpholino)methanone" is a chemical compound with the molecular formula C11H12FNO2. It is a white solid that is used in scientific research as a building block for the synthesis of various pharmaceutical compounds. The compound contains a morpholino group and a fluorophenyl group, which are both important for its reactivity and potential biological activity. Its structure suggests that it may have potential as a drug or as a precursor for drug development, although further research would be needed to confirm this. As with any chemical compound, proper handling and safety precautions should be taken when working with "(4-Fluorophenyl)(morpholino)methanone" to avoid potential health hazards.

InChI:InChI=1/C11H12FNO2/c12-10-3-1-9(2-4-10)11(14)13-5-7-15-8-6-13/h1-4H,5-8H2

Upstream product

• 110-91-8 morpholine 
• 459-57-4 4-fluorobenzaldehyde 
• 456-22-4 4-Fluorobenzoic acid 
• 459-56-3 4-fluorobenzylic alcohol 
• 352-34-1 4-fluoro-1-iodobenzene 
• 201230-82-2 carbon monoxide 
• 10024-89-2 morpholin hydrochloride 
• 403-43-0 4-fluorobenzoyl chloride 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 23328-69-0 4-chloromorpholine 
• 1590389-14-2 potassium trifluoro(4-fluorobenzoyl)borate 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1283075-99-9 dipropan-2-yl 1-(4-fluorobenzoyl)hydrazine-1,2-dicarboxylate 
• 451-46-7 4-fluorobenzoic acid ethyl ester 

Downstream Products

• 13169-73-8 (4-fluorophenyl)(1H-pyrrol-2-yl)methanone 
• 1443667-03-5 1,9-bis(4-fluorobenzoyl)-5-(4-nitrophenyl)dipyrromethane 
• 1443667-05-7 4-[15-(4-nitro-phenyl)-10,20-di-(4-fluoro)phenylporphyrin-5-yl]methyl benzoate 
• 1443667-07-9 15-(4-carbomethoxyphenyl)-5-(4-aminophenyl)-10,20-bis-(4-fluorophenyl)porphyrin 
• 1443667-11-5 5-(4-(N-Acetylaminophenyl))-10,20-bis(4-fluorophenyl)-15-(4-(methoxycarbonylphenyl)) porphyrin 
• 1528751-50-9 ethyl {2-[(4-fluorophenyl)carbonyl]-1H-pyrrol-1-yl}acetate 
• 154047-20-8 (1-Allyl-1H-pyrrol-2-yl)-(4-fluoro-phenyl)-methanol 
• 154047-01-5 (1-Allyl-1H-pyrrol-2-yl)-(4-fluoro-phenyl)-methanone 

Relevant articles and documents

Radical Decarboxylative Carbometalation of Benzoic Acids: A Solution to Aromatic Decarboxylative Fluorination

Abundant aromatic carboxylic acids exist in great structural diversity from nature and synthesis. To date, the synthetically valuable decarboxylative functionalization of benzoic acids is realized mainly by transition-metal-catalyzed decarboxylative cross couplings. However, the high activation barrier for thermal decarboxylative carbometalation that often requires 140 °C reaction temperature limits both the substrate scope as well as the scope of suitable reactions that can sustain such conditions. Numerous reactions, for example, decarboxylative fluorination that is well developed for aliphatic carboxylic acids, are out of reach for the aromatic counterparts with current reaction chemistry. Here, we report a conceptually different approach through a low-barrier photoinduced ligand to metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation strategy, which generates a putative high-valent arylcopper(III) complex, from which versatile facile reductive eliminations can occur. We demonstrate the suitability of our new approach to address previously unrealized general decarboxylative fluorination of benzoic acids.

Phenysilane and Silicon Tetraacetate: Versatile Promotors for Amide Synthesis

Phenylsilane was reevaluated as a useful coupling reagent for amide synthesis. At room temperature, a wide range of amides and peptides were obtained in good to excellent yields (up to 99 %). For the first time, Weinreb amides synthesis mediated by a hydrosilane were also documented. Comparative experiments with various acetoxysilanes suggested the involvement of a phenyl-triacyloxysilane. From this mechanistic study, silicon tetraacetate was shown as an efficient amine acylating agent.

Tandem Photoredox Catalysis: Enabling Carbonylative Amidation of Aryl and Alkylhalides

We report a new visible-light-mediated carbonylative amidation of aryl, heteroaryl, and alkyl halides. A tandem catalytic cycle of [Ir(ppy)2(dtb-bpy)]+ generates a potent iridium photoreductant through a second catalytic cycle in the presence of DIPEA, which productively engages aryl bromides, iodides, and even chlorides as well as primary, secondary, and tertiary alkyl iodides. The versatile in situ generated catalyst is compatible with aliphatic and aromatic amines, shows high functional-group tolerance, and enables the late-stage amidation of complex natural products.