Technology Process of 3-Methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol
There total 2 articles about 3-Methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II); potassium acetate;
In
1,4-dioxane; toluene;
at 95 ℃;
for 16h;
Inert atmosphere;
DOI:10.1021/jacs.6b00356
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 2,6-dimethylpyridine; dmap / dichloromethane / 3 h / 0 - 20 °C
2: methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II); potassium acetate / toluene; 1,4-dioxane / 16 h / 95 °C / Inert atmosphere
With
2,6-dimethylpyridine; dmap; methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II); potassium acetate;
In
1,4-dioxane; dichloromethane; toluene;
DOI:10.1021/jacs.6b00356
- Guidance literature:
-
3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; ethyl iodide;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 90 ℃;
With
sodium periodate;
In
tetrahydrofuran; water;
for 0.25h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 20 ℃;
for 4h;
DOI:10.1021/jacs.6b00356
