2,2-Dimethyl-propionic acid 2-(2,2-dimethyl-propionyloxy)-5-(2-hydroxy-1-methylamino-ethyl)-phenyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid 2-(2,2-dimethyl-propionyloxy)-5-(2-hydroxy-1-methylamino-ethyl)-phenyl ester
CAS No.:133789-76-1
Molecular Formula:C₁₉H₂₉NO₅
Molecular Weight:351.443
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid 2-(2,2-dimethyl-propionyloxy)-5-(2-hydroxy-1-methylamino-ethyl)-phenyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid 2-(2,2-dimethyl-propionyloxy)-5-(2-hydroxy-1-methylamino-ethyl)-phenyl ester

Chemical Property:

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Technology Process of 2,2-Dimethyl-propionic acid 2-(2,2-dimethyl-propionyloxy)-5-(2-hydroxy-1-methylamino-ethyl)-phenyl ester

There total 12 articles about 2,2-Dimethyl-propionic acid 2-(2,2-dimethyl-propionyloxy)-5-(2-hydroxy-1-methylamino-ethyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 133801-00-0
2,2-Dimethyl-propionic acid 5-[1-(benzyl-methyl-amino)-2-hydroxy-ethyl]-2-(2,2-dimethyl-propionyloxy)-phenyl ester

: 133789-76-1
2,2-Dimethyl-propionic acid 2-(2,2-dimethyl-propionyloxy)-5-(2-hydroxy-1-methylamino-ethyl)-phenyl ester

Guidance literature:: With hydrogenchloride; palladium on activated charcoal; In ethanol; under 11400 Torr;
DOI:10.1002/hlca.19910740216

Reference yield:

: 3282-30-2
pivaloyl chloride

: 133789-76-1
2,2-Dimethyl-propionic acid 2-(2,2-dimethyl-propionyloxy)-5-(2-hydroxy-1-methylamino-ethyl)-phenyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / Et₃N / tetrahydrofuran / 3 h / 25 °C

2: 1.) LDA / 1.) 0 deg C, THF, 1 h 2.) -78 deg C, THF, 4 h

3: 80 percent / activated MnO₂ / CH₂Cl₂ / 2 h

4: 90 percent / DIBAL / tetrahydrofuran / 1 h / -78 °C

5: 65 percent / Al-Hg / tetrahydrofuran; H₂O / 12 h / Ambient temperature

6: 1.) Me₃OBF₄ 2.) K₂CO₃ / 1.) MeNO₂, 0 deg C, 1 h 2.) CH₂Cl₂, MeOH/H₂O, r. t.

7: tetrahydrofuran / 6 h

8: 16 percent / 10percent Pd-C, 1.2 N HCl / ethanol / 11400 Torr

With hydrogenchloride; manganese(IV) oxide; palladium on activated charcoal; aluminium amalgam; trimethoxonium tetrafluoroborate; diisobutylaluminium hydride; potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1002/hlca.19910740216

Reference yield:

: 84260-69-5
4-formyl-1,2-phenylene bis(2,2-dimethylpropanoate)

: 133789-76-1
2,2-Dimethyl-propionic acid 2-(2,2-dimethyl-propionyloxy)-5-(2-hydroxy-1-methylamino-ethyl)-phenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) LDA / 1.) 0 deg C, THF, 1 h 2.) -78 deg C, THF, 4 h

2: 80 percent / activated MnO₂ / CH₂Cl₂ / 2 h

3: 90 percent / DIBAL / tetrahydrofuran / 1 h / -78 °C

4: 65 percent / Al-Hg / tetrahydrofuran; H₂O / 12 h / Ambient temperature

5: 1.) Me₃OBF₄ 2.) K₂CO₃ / 1.) MeNO₂, 0 deg C, 1 h 2.) CH₂Cl₂, MeOH/H₂O, r. t.

6: tetrahydrofuran / 6 h

7: 16 percent / 10percent Pd-C, 1.2 N HCl / ethanol / 11400 Torr

With hydrogenchloride; manganese(IV) oxide; palladium on activated charcoal; aluminium amalgam; trimethoxonium tetrafluoroborate; diisobutylaluminium hydride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1002/hlca.19910740216