2,2-Dimethyl-propionic acid 5-[1-(benzyl-methyl-amino)-2-hydroxy-ethyl]-2-(2,2-dimethyl-propionyloxy)-phenyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid 5-[1-(benzyl-methyl-amino)-2-hydroxy-ethyl]-2-(2,2-dimethyl-propionyloxy)-phenyl ester
CAS No.:133801-00-0
Molecular Formula:C₂₆H₃₅NO₅
Molecular Weight:441.568
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid 5-[1-(benzyl-methyl-amino)-2-hydroxy-ethyl]-2-(2,2-dimethyl-propionyloxy)-phenyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid 5-[1-(benzyl-methyl-amino)-2-hydroxy-ethyl]-2-(2,2-dimethyl-propionyloxy)-phenyl ester

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Technology Process of 2,2-Dimethyl-propionic acid 5-[1-(benzyl-methyl-amino)-2-hydroxy-ethyl]-2-(2,2-dimethyl-propionyloxy)-phenyl ester

There total 11 articles about 2,2-Dimethyl-propionic acid 5-[1-(benzyl-methyl-amino)-2-hydroxy-ethyl]-2-(2,2-dimethyl-propionyloxy)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3282-30-2
pivaloyl chloride

: 133801-00-0
2,2-Dimethyl-propionic acid 5-[1-(benzyl-methyl-amino)-2-hydroxy-ethyl]-2-(2,2-dimethyl-propionyloxy)-phenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / Et₃N / tetrahydrofuran / 3 h / 25 °C

2: 1.) LDA / 1.) 0 deg C, THF, 1 h 2.) -78 deg C, THF, 4 h

3: 80 percent / activated MnO₂ / CH₂Cl₂ / 2 h

4: 90 percent / DIBAL / tetrahydrofuran / 1 h / -78 °C

5: 65 percent / Al-Hg / tetrahydrofuran; H₂O / 12 h / Ambient temperature

6: 1.) Me₃OBF₄ 2.) K₂CO₃ / 1.) MeNO₂, 0 deg C, 1 h 2.) CH₂Cl₂, MeOH/H₂O, r. t.

7: tetrahydrofuran / 6 h

With manganese(IV) oxide; aluminium amalgam; trimethoxonium tetrafluoroborate; diisobutylaluminium hydride; potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/hlca.19910740216

Reference yield:

: 84260-69-5
4-formyl-1,2-phenylene bis(2,2-dimethylpropanoate)

: 133801-00-0
2,2-Dimethyl-propionic acid 5-[1-(benzyl-methyl-amino)-2-hydroxy-ethyl]-2-(2,2-dimethyl-propionyloxy)-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LDA / 1.) 0 deg C, THF, 1 h 2.) -78 deg C, THF, 4 h

2: 80 percent / activated MnO₂ / CH₂Cl₂ / 2 h

3: 90 percent / DIBAL / tetrahydrofuran / 1 h / -78 °C

4: 65 percent / Al-Hg / tetrahydrofuran; H₂O / 12 h / Ambient temperature

5: 1.) Me₃OBF₄ 2.) K₂CO₃ / 1.) MeNO₂, 0 deg C, 1 h 2.) CH₂Cl₂, MeOH/H₂O, r. t.

6: tetrahydrofuran / 6 h

With manganese(IV) oxide; aluminium amalgam; trimethoxonium tetrafluoroborate; diisobutylaluminium hydride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/hlca.19910740216

Reference yield:

: 133789-69-2
(R)-1-<3',4'-bis<(pivaloyl)oxy>phenyl>-2-(p-tolylsulfinyl)ethan-1-on

: 133801-00-0
2,2-Dimethyl-propionic acid 5-[1-(benzyl-methyl-amino)-2-hydroxy-ethyl]-2-(2,2-dimethyl-propionyloxy)-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / DIBAL / tetrahydrofuran / 1 h / -78 °C

2: 65 percent / Al-Hg / tetrahydrofuran; H₂O / 12 h / Ambient temperature

3: 1.) Me₃OBF₄ 2.) K₂CO₃ / 1.) MeNO₂, 0 deg C, 1 h 2.) CH₂Cl₂, MeOH/H₂O, r. t.

4: tetrahydrofuran / 6 h

With aluminium amalgam; trimethoxonium tetrafluoroborate; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; water;
DOI:10.1002/hlca.19910740216