5,6-Dihydroindolo[1,2-c]quinazoline

Base Information

• Chemical Name: 5,6-Dihydroindolo[1,2-c]quinazoline
• CAS No.: 159021-55-3
• Molecular Formula: C₁₅H₁₂N₂
• Molecular Weight: 220.274
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40434906
• Wikidata: Q82249498
• Mol file: 159021-55-3.mol

Synonyms:159021-55-3;5,6-Dihydroindolo[1,2-c]quinazoline;5,6-DIHYDRO-INDOLO[1,2-C]QUINAZOLINE;DTXSID40434906;FENOPROFENCALCIUMSALTDIHYDRATE;SB33971;FT-0743693

Chemical Property of 5,6-Dihydroindolo[1,2-c]quinazoline

Chemical Property:

• PSA: 16.96000
• LogP: 3.82930
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 220.100048391
• Heavy Atom Count: 17
• Complexity: 291

Purity/Quality:

98% ^*data from raw suppliers

5,6-Dihydroindolo[1,2-c]quinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1NC2=CC=CC=C2C3=CC4=CC=CC=C4N31

Technology Process of 5,6-Dihydroindolo[1,2-c]quinazoline

There total 4 articles about 5,6-Dihydroindolo[1,2-c]quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

indolo<1,2-c>quinazoline (239-43-0) → 5,6-dihydroindolo<1,2-c>quinazoline (159021-55-3)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 5h; Heating;

DOI:10.1021/jo00101a043

Reference yield:

2-(2-aminophenyl)-1H-indole (32566-01-1) → 5,6-dihydroindolo<1,2-c>quinazoline (159021-55-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / H₂O / 1 h / 90 °C

2: 80 percent / NaBH₄ / methanol / 5 h / Heating

With sodium tetrahydroborate; In methanol; water;

DOI:10.1021/jo00101a043

Reference yield:

2-(1-(2-phenylhydrazineylidene)ethyl)aniline (40754-13-0) → 5,6-dihydroindolo<1,2-c>quinazoline (159021-55-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / CH₃SO₃H, P₂O₅ / 0.5 h / 80 °C

2: 73 percent / H₂O / 1 h / 90 °C

3: 80 percent / NaBH₄ / methanol / 5 h / Heating

With sodium tetrahydroborate; methanesulfonic acid; phosphorus pentoxide; In methanol; water;

DOI:10.1021/jo00101a043

upstream raw materials:

indolo<1,2-c>quinazoline

2-(2-aminophenyl)-1H-indole

2-(1-(2-phenylhydrazineylidene)ethyl)aniline

2-aminoacetophenone

Downstream raw materials:

2-(5-Acetyl-5,6-dihydro-indolo[1,2-c]quinazolin-12-yl)-2-oxo-N-(2-phenylselanyl-ethyl)-acetamide