4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

Base Information

Chemical Name:4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine
CAS No.:1287783-10-1
Molecular Formula:C₂₇H₃₉NO₅Si
Molecular Weight:485.696
Hs Code.:

Synonyms:4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

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Chemical Property of 4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

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Technology Process of 4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

There total 7 articles about 4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.6%

: 1287783-09-8
2-(2-(2-(2-(4-(methylamino)phenyl)benzofuran-5-yloxy)ethoxy)ethoxy)ethanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1287783-10-1
4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jm200057u

Reference yield:

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 1287783-10-1
4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / Reflux

2.1: tin(ll) chloride / ethanol / 2 h / Reflux

3.1: sodium methylate / methanol / 1 h / Reflux

3.2: 2 h / Reflux

4.1: boron tribromide / dichloromethane / 1 h / 20 °C / Cooling with ice

4.2: Cooling with ice

5.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

6.1: 1H-imidazole / dichloromethane / 4 h / 20 °C

With 1H-imidazole; sodium methylate; boron tribromide; potassium carbonate; tin(ll) chloride; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200057u

Reference yield:

: 888704-00-5
[4-(5-methoxy-benzofuran-2-yl)-phenyl]-methyl-amine

: 1287783-10-1
4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron tribromide / dichloromethane / 1 h / 20 °C / Cooling with ice

1.2: Cooling with ice

2.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

3.1: 1H-imidazole / dichloromethane / 4 h / 20 °C

With 1H-imidazole; boron tribromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200057u