4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

Base Information

Chemical Name:4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester
CAS No.:1402048-48-9
Molecular Formula:C₄₅H₆₆N₂O₅S₂
Molecular Weight:779.161
Hs Code.:

4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

Synonyms:4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

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Chemical Property of 4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

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Technology Process of 4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

There total 5 articles about 4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 66414-05-9
2-ethyloxycarbonyl-3-ethyl-5-methyl-pyrrole-4-carboxylic acid

: 1402048-10-5
2,6-di-tert-butyl-4-[4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-4-ylsulfanyl]-phenol

: 1402048-48-9
4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

Guidance literature:: 2-ethyloxycarbonyl-3-ethyl-5-methyl-pyrrole-4-carboxylic acid; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 18h;

2,6-di-tert-butyl-4-[4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-4-ylsulfanyl]-phenol; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 1402048-09-2
4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carboxylic acid ethyl ester

: 1402048-48-9
4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

1.2: 20 °C / pH ~ 6

2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C

2.2: 1 h / 20 °C

With thionyl chloride; isopropyl alcohol; potassium hydroxide; N,N-dimethyl-formamide; In dichloromethane;

Reference yield:

: 950-59-4
4-hydroxy-3,5-di-tert-butylthiophenol

: 1402048-48-9
4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol / 20 h / 45 °C

2.1: potassium tert-butylate / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

3.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

3.2: 20 °C / pH ~ 6

4.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C

4.2: 1 h / 20 °C

With hydrogenchloride; thionyl chloride; potassium tert-butylate; isopropyl alcohol; potassium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane;