4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid

Base Information

Chemical Name:4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid
CAS No.:1402048-49-0
Molecular Formula:C₄₃H₆₂N₂O₅S₂
Molecular Weight:751.108
Hs Code.:

4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid

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Chemical Property of 4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid

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Technology Process of 4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid

There total 6 articles about 4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1402048-48-9
4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

: 1402048-49-0
4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid

Guidance literature:: 4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 5h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 1402048-09-2
4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carboxylic acid ethyl ester

: 1402048-49-0
4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

1.2: 20 °C / pH ~ 6

2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C

2.2: 1 h / 20 °C

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 5 h / 20 °C

With thionyl chloride; lithium hydroxide monohydrate; water; isopropyl alcohol; potassium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 950-59-4
4-hydroxy-3,5-di-tert-butylthiophenol

: 1402048-49-0
4-[4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carbonyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / methanol / 20 h / 45 °C

2.1: potassium tert-butylate / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

3.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

3.2: 20 °C / pH ~ 6

4.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C

4.2: 1 h / 20 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 5 h / 20 °C

With hydrogenchloride; thionyl chloride; lithium hydroxide monohydrate; potassium tert-butylate; water; isopropyl alcohol; potassium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane;