3-methoxy-5-(2-phenyl-4-(pyridine-4-yl)thiazol-5-yl)pyridine-2-amine trifluoroacetate

Base Information

Chemical Name:3-methoxy-5-(2-phenyl-4-(pyridine-4-yl)thiazol-5-yl)pyridine-2-amine trifluoroacetate
CAS No.:1450020-21-9
Molecular Formula:C₂HF₃O₂*C₂₀H₁₆N₄OS
Molecular Weight:474.463
Hs Code.:

Synonyms:3-methoxy-5-(2-phenyl-4-(pyridine-4-yl)thiazol-5-yl)pyridine-2-amine trifluoroacetate

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Chemical Property of 3-methoxy-5-(2-phenyl-4-(pyridine-4-yl)thiazol-5-yl)pyridine-2-amine trifluoroacetate

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Technology Process of 3-methoxy-5-(2-phenyl-4-(pyridine-4-yl)thiazol-5-yl)pyridine-2-amine trifluoroacetate

There total 9 articles about 3-methoxy-5-(2-phenyl-4-(pyridine-4-yl)thiazol-5-yl)pyridine-2-amine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 947249-19-6
3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)pyridine-2-amine

: 1188301-89-4
5-bromo-2-phenyl-4-(pyridin-4-yl)thiazole

: 76-05-1
trifluoroacetic acid

: 1450020-21-9
3-methoxy-5-(2-phenyl-4-(pyridine-4-yl)thiazol-5-yl)pyridine-2-amine trifluoroacetate

Guidance literature:: 3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)pyridine-2-amine; 5-bromo-2-phenyl-4-(pyridin-4-yl)thiazole; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; at 120 ℃; for 0.25h; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 20265-37-6
3-methoxy-2-nitropyridine

: 1450020-21-9
3-methoxy-5-(2-phenyl-4-(pyridine-4-yl)thiazol-5-yl)pyridine-2-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 3 h

2.1: bromine; sulfuric acid; acetic acid / water / 2 h / 3 - 5 °C

2.2: pH 8 / Cooling with ice

3.1: potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane / 6 h / 110 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 0.25 h / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; palladium 10% on activated carbon; hydrogen; bromine; potassium acetate; potassium carbonate; acetic acid; tricyclohexylphosphine; In 1,4-dioxane; methanol; water; ethyl acetate; 4.1: |Suzuki Coupling;

Reference yield:

: 10201-71-5
3-methoxypyridin-2-amine

: 1450020-21-9
3-methoxy-5-(2-phenyl-4-(pyridine-4-yl)thiazol-5-yl)pyridine-2-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine; sulfuric acid; acetic acid / water / 2 h / 3 - 5 °C

1.2: pH 8 / Cooling with ice

2.1: potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane / 6 h / 110 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 0.25 h / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; bromine; potassium acetate; potassium carbonate; acetic acid; tricyclohexylphosphine; In 1,4-dioxane; water; 3.1: |Suzuki Coupling;