{2-acetyl-5-methyl-1-benzothien-3-yl}acetic acid phenylhydrazone

Base Information

• Chemical Name: {2-acetyl-5-methyl-1-benzothien-3-yl}acetic acid phenylhydrazone
• CAS No.: 1416134-68-3
• Molecular Formula: C₁₉H₁₈N₂O₂S
• Molecular Weight: 338.43
• Mol file: 1416134-68-3.mol

Synonyms:{2-acetyl-5-methyl-1-benzothien-3-yl}acetic acid phenylhydrazone

Chemical Property of {2-acetyl-5-methyl-1-benzothien-3-yl}acetic acid phenylhydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-acetyl-5-methyl-1-benzothien-3-yl}acetic acid phenylhydrazone

There total 3 articles about {2-acetyl-5-methyl-1-benzothien-3-yl}acetic acid phenylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-acetyl-5-methylbenzo[b]thiophene-3-acetic acid (1416135-07-3) + phenylhydrazine (100-63-0) → {2-acetyl-5-methyl-1-benzothien-3-yl}acetic acid phenylhydrazone (1416134-68-3)

Guidance literature:

In isopropyl alcohol; for 1h; Reflux;

DOI:10.1007/s10593-012-1146-4

Reference yield:

1,6-dimethyl[1]benzothieno[2,3-c]pyran-3-one → {2-acetyl-5-methyl-1-benzothien-3-yl}acetic acid phenylhydrazone (1416134-68-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water

2: isopropyl alcohol / 1 h / Reflux

With sodium hydroxide; In water; isopropyl alcohol;

DOI:10.1007/s10593-012-1146-4

Reference yield:

5-methylbenzo[b]thiophene-3-acetic acid (1735-12-2) → {2-acetyl-5-methyl-1-benzothien-3-yl}acetic acid phenylhydrazone (1416134-68-3)

Guidance literature:

Multi-step reaction with 3 steps

1: boron trifluoride diethyl etherate

2: sodium hydroxide / water

3: isopropyl alcohol / 1 h / Reflux

With boron trifluoride diethyl etherate; sodium hydroxide; In water; isopropyl alcohol;

DOI:10.1007/s10593-012-1146-4

upstream raw materials:

2-acetyl-5-methylbenzo[b]thiophene-3-acetic acid

phenylhydrazine

5-methylbenzo[b]thiophene-3-acetic acid

Downstream raw materials:

2-anilino-1,6-dimethyl[1]benzothieno[2,3-c]pyridin-3(2H)-one