2-(1-bromoethyl)-4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinoline

Base Information

Chemical Name:2-(1-bromoethyl)-4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinoline
CAS No.:1259522-05-8
Molecular Formula:C₂₅H₃₁BrFNOSSi
Molecular Weight:520.581
Hs Code.:

Synonyms:2-(1-bromoethyl)-4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinoline

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Chemical Property of 2-(1-bromoethyl)-4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinoline

Chemical Property:

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Technology Process of 2-(1-bromoethyl)-4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinoline

There total 10 articles about 2-(1-bromoethyl)-4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259522-04-7
4-(2-(tert-butyldimethylsilyloxy)ethylthio)-2-ethyl-6-fluoro-3-phenylquinoline

: 1259522-05-8
2-(1-bromoethyl)-4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinoline

Guidance literature:: 4-(2-(tert-butyldimethylsilyloxy)ethylthio)-2-ethyl-6-fluoro-3-phenylquinoline; With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; dibenzoyl peroxide; In tetrachloromethane; for 3h; Reflux;

With sodium hydrogencarbonate; In tetrachloromethane; water;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1259522-05-8
2-(1-bromoethyl)-4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 60 °C

2: potassium carbonate; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex / tetrahydrofuran / 6 h / Reflux

3: N,N-dimethyl-formamide / 16 h / 100 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 2 h

5: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 3 h / Reflux

With 1H-imidazole; N-Bromosuccinimide; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2015.01.001

Reference yield:

: 1259521-34-0
4-chloro-2-ethyl-6-fluoro-3-phenylquinoline

: 1259522-05-8
2-(1-bromoethyl)-4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 16 h / 100 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 2 h

3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 3 h / Reflux

With 1H-imidazole; N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2015.01.001