10-methoxy-5,6,7,8,13,13a-hexahydro-2H-1,3-dioxolano[4,5-g]isoquinolino[3,2-a]isoquinolin-9-yl 4-nitrobenzenesulfonate

Base Information

Chemical Name:10-methoxy-5,6,7,8,13,13a-hexahydro-2H-1,3-dioxolano[4,5-g]isoquinolino[3,2-a]isoquinolin-9-yl 4-nitrobenzenesulfonate
CAS No.:1095271-71-8
Molecular Formula:C₂₅H₂₂N₂O₈S
Molecular Weight:510.524
Hs Code.:

Synonyms:10-methoxy-5,6,7,8,13,13a-hexahydro-2H-1,3-dioxolano[4,5-g]isoquinolino[3,2-a]isoquinolin-9-yl 4-nitrobenzenesulfonate

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Chemical Property of 10-methoxy-5,6,7,8,13,13a-hexahydro-2H-1,3-dioxolano[4,5-g]isoquinolino[3,2-a]isoquinolin-9-yl 4-nitrobenzenesulfonate

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Technology Process of 10-methoxy-5,6,7,8,13,13a-hexahydro-2H-1,3-dioxolano[4,5-g]isoquinolino[3,2-a]isoquinolin-9-yl 4-nitrobenzenesulfonate

There total 5 articles about 10-methoxy-5,6,7,8,13,13a-hexahydro-2H-1,3-dioxolano[4,5-g]isoquinolino[3,2-a]isoquinolin-9-yl 4-nitrobenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.9%

: 1095272-04-0
2,3-methylenedioxy-9-((p-nitrophenylsulfonyl)oxy)-10-methoxyprotoberberine chloride

: 1095271-71-8
10-methoxy-5,6,7,8,13,13a-hexahydro-2H-1,3-dioxolano[4,5-g]isoquinolino[3,2-a]isoquinolin-9-yl 4-nitrobenzenesulfonate

Guidance literature:: With sodium tetrahydroborate; In methanol; for 3h; Product distribution / selectivity; Heating / reflux;

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 17388-17-9
(+/-)-nandinine

: 1095271-71-8
10-methoxy-5,6,7,8,13,13a-hexahydro-2H-1,3-dioxolano[4,5-g]isoquinolino[3,2-a]isoquinolin-9-yl 4-nitrobenzenesulfonate

Guidance literature:: With triethylamine; In dichloromethane; Reflux;
DOI:10.1016/j.bioorg.2022.105665

Reference yield:

: 15401-69-1
berberrubine chloride

: 1095271-71-8
10-methoxy-5,6,7,8,13,13a-hexahydro-2H-1,3-dioxolano[4,5-g]isoquinolino[3,2-a]isoquinolin-9-yl 4-nitrobenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: chloroform / 7 h / 70 °C

2: sodium tetrahydroborate; methanol / 3 h / Reflux

With methanol; sodium tetrahydroborate; In chloroform;