(R)-2-((S)-2-hydroxy-1-phenylethylamino)-2-(1-methylcyclopropyl)acetonitrile

Base Information

Chemical Name:(R)-2-((S)-2-hydroxy-1-phenylethylamino)-2-(1-methylcyclopropyl)acetonitrile
CAS No.:1334675-13-6
Molecular Formula:C₁₄H₁₈N₂O
Molecular Weight:230.31
Hs Code.:

Synonyms:(R)-2-((S)-2-hydroxy-1-phenylethylamino)-2-(1-methylcyclopropyl)acetonitrile

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Chemical Property of (R)-2-((S)-2-hydroxy-1-phenylethylamino)-2-(1-methylcyclopropyl)acetonitrile

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Technology Process of (R)-2-((S)-2-hydroxy-1-phenylethylamino)-2-(1-methylcyclopropyl)acetonitrile

There total 2 articles about (R)-2-((S)-2-hydroxy-1-phenylethylamino)-2-(1-methylcyclopropyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 4515-89-3
1-methylcyclopropanecarbaldehyde

: 20989-17-7
(2S)-2-phenylglycinol

: 1334675-13-6
(R)-2-((S)-2-hydroxy-1-phenylethylamino)-2-(1-methylcyclopropyl)acetonitrile

Guidance literature:: 1-methylcyclopropanecarbaldehyde; (2S)-2-phenylglycinol; With magnesium sulfate; In chloroform; at 20 ℃; for 3h;

trimethylsilyl cyanide; In chloroform; at 0 - 20 ℃;

With hydrogenchloride; In chloroform; water; for 0.0833333h;

Reference yield:

: 2746-14-7
1-methylcyclopropanemethanol

: 1334675-13-6
(R)-2-((S)-2-hydroxy-1-phenylethylamino)-2-(1-methylcyclopropyl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridinium chlorochromate / dichloromethane / 20 °C

2.1: magnesium sulfate / chloroform / 3 h / 20 °C

2.2: 0 - 20 °C

2.3: 0.08 h

With magnesium sulfate; pyridinium chlorochromate; In dichloromethane; chloroform;

Reference yield: 92.0%

: 1334675-13-6
(R)-2-((S)-2-hydroxy-1-phenylethylamino)-2-(1-methylcyclopropyl)acetonitrile

: 1334675-14-7
(R)-2-((S)-2-hydroxy-1-phenylethylamino)-2-(1-methylcyclopropyl)acetic acid

Guidance literature:: (R)-2-((S)-2-hydroxy-1-phenylethylamino)-2-(1-methylcyclopropyl)acetonitrile; With hydrogenchloride; water; at 100 ℃; for 20h;

With sodium hydroxide; In water; pH=8;