N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-tert-butylamide

Base Information

• Chemical Name: N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-tert-butylamide
• CAS No.: 102651-05-8
• Molecular Formula: C₂₁H₃₂N₂O₅
• Molecular Weight: 392.495
• Mol file: 102651-05-8.mol

Synonyms:N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-tert-butylamide

Chemical Property of N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-tert-butylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-tert-butylamide

There total 2 articles about N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-tert-butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Boc-Glu-OBn (30924-93-7) + tert-butylamine (75-64-9) → N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-tert-butylamide (102651-05-8)

Guidance literature:

With diphenylphosphoranyl azide; diethylamine; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 45h;

DOI:10.1021/jm00159a023

Reference yield: 98.0%

→ N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-tert-butylamide (102651-05-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h; Inert atmosphere;

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield: 100.0%

N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-tert-butylamide (102651-05-8) + trifluoroacetic acid (76-05-1) → C16H24N2O3*C2HF3O2

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 5h;

upstream raw materials:

Boc-Glu-OBn

tert-butylamine

Downstream raw materials:

L-glutamic acid α-benzyl ester γ-tert-butylamide p-toluenesulfonate salt

(10)N-formylaminopterin γ-tert-butylamide

(10)N-formylaminopterin α-benzyl ester γ-tert-butylamide hemi p-toluenesulfonate salts