[7-(4-phenylthiazol-2-yl)naphthalen-2-yl]carbamic acid tert-butyl ester

Base Information

Chemical Name:[7-(4-phenylthiazol-2-yl)naphthalen-2-yl]carbamic acid tert-butyl ester
CAS No.:1613317-35-3
Molecular Formula:C₂₄H₂₂N₂O₂S
Molecular Weight:402.517
Hs Code.:

Synonyms:[7-(4-phenylthiazol-2-yl)naphthalen-2-yl]carbamic acid tert-butyl ester

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Chemical Property of [7-(4-phenylthiazol-2-yl)naphthalen-2-yl]carbamic acid tert-butyl ester

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Technology Process of [7-(4-phenylthiazol-2-yl)naphthalen-2-yl]carbamic acid tert-butyl ester

There total 6 articles about [7-(4-phenylthiazol-2-yl)naphthalen-2-yl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1613219-39-8
7-(4-phenylthiazol-2-yl)-naphthalene-2-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 1613317-35-3
[7-(4-phenylthiazol-2-yl)naphthalen-2-yl]carbamic acid tert-butyl ester

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; at 120 ℃; for 1h; Sealed tube; Microwave irradiation; Inert atmosphere;

Reference yield:

: 5043-14-1
7-bromonaphthalene-2-carboxylic acid

: 1613317-35-3
[7-(4-phenylthiazol-2-yl)naphthalen-2-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 18 h / Reflux; Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

4: lithium hydroxide; water / methanol; tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

5: diphenyl phosphoryl azide; triethylamine / 1 h / 120 °C / Sealed tube; Microwave irradiation; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; diphenyl phosphoryl azide; water; potassium acetate; caesium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; 3: |Suzuki Coupling / 5: |Curtius Rearrangement;

Reference yield:

: 1613219-65-0
7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-naphthalene-2-carboxylic acid methyl ester

: 1613317-35-3
[7-(4-phenylthiazol-2-yl)naphthalen-2-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

2: lithium hydroxide; water / methanol; tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

3: diphenyl phosphoryl azide; triethylamine / 1 h / 120 °C / Sealed tube; Microwave irradiation; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; water; caesium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1: |Suzuki Coupling / 3: |Curtius Rearrangement;