Carbamic acid, [2-(dimethylamino)-1-methoxy-2-oxoethyl]-, methyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, [2-(dimethylamino)-1-methoxy-2-oxoethyl]-, methyl ester (9CI)
• CAS No.: 143995-57-7
• Molecular Formula: C₇H₁₄N₂O₄
• Molecular Weight: 190.199
• DSSTox Substance ID: DTXSID50567214
• Mol file: 143995-57-7.mol

Synonyms:143995-57-7;Carbamic acid, [2-(dimethylamino)-1-methoxy-2-oxoethyl]-, methyl ester (9CI);methyl N-[2-(dimethylamino)-1-methoxy-2-oxoethyl]carbamate;Carbamic acid, [2-(dimethylamino)-1-methoxy-2-oxoethyl]-, methyl ester (9CI);DTXSID50567214;Methyl [2-(dimethylamino)-1-methoxy-2-oxoethyl]carbamate;Carbamic acid,[2-(dimethylamino)-1-methoxy-2-oxoethyl]-,methyl ester(9ci)

Chemical Property of Carbamic acid, [2-(dimethylamino)-1-methoxy-2-oxoethyl]-, methyl ester (9CI)

Chemical Property:

• PSA: 71.36000
• LogP: -0.39250
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 190.09535693
• Heavy Atom Count: 13
• Complexity: 193

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C(=O)C(NC(=O)OC)OC

Technology Process of Carbamic acid, [2-(dimethylamino)-1-methoxy-2-oxoethyl]-, methyl ester (9CI)

There total 1 articles about Carbamic acid, [2-(dimethylamino)-1-methoxy-2-oxoethyl]-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2--2-methoxyethanoate (143995-55-5) + dimethyl amine (124-40-3) → 2-Methoxy-2-(methoxycarbonylamino)-N,N-dimethylacetamide (143995-57-7)

Guidance literature:

sodium cyanide; In methanol; for 1h; 0 deg C to room temp.;

DOI:10.1002/recl.19921110705

Reference yield: 60.0%

1-(Trimethylsilyloxy)cyclohexene (6651-36-1) + 2-Methoxy-2-(methoxycarbonylamino)-N,N-dimethylacetamide (143995-57-7) → 2-(Methoxycarbonylamino)-N,N-dimethylamino-2-(2-oxocyclohexyl)acetamide (143995-65-7)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; 1) -78 deg C, 15 min, 2) room temp., 3 h;

DOI:10.1002/recl.19921110705

Reference yield: 51.0%

1-styrenyloxytrimethylsilane (13735-81-4) + 2-Methoxy-2-(methoxycarbonylamino)-N,N-dimethylacetamide (143995-57-7) → 2-(Methoxycarbonylamino)-N,N-dimethylamino-4-oxo-4-phenylbutanamide (143995-66-8)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; 1) -78 deg C, 15 min, 2) room temp., 3 h;

DOI:10.1002/recl.19921110705

upstream raw materials:

2--2-methoxyethanoate

dimethyl amine

Downstream raw materials:

2-(Methoxycarbonylamino)-N,N-dimethylamino-4-oxo-4-phenylbutanamide

2-(Methoxycarbonylamino)-N,N-dimethylamino-2-(2-oxocyclohexyl)acetamide