(+/-)-3-<(4-Tertio-butyl dimethylsiloxy)-3-methoxybenzyl>butan-4-olide

Base Information

• Chemical Name: (+/-)-3-<(4-Tertio-butyl dimethylsiloxy)-3-methoxybenzyl>butan-4-olide
• CAS No.: 140193-23-3
• Molecular Formula: C₁₈H₂₈O₄Si
• Molecular Weight: 336.503
• Mol file: 140193-23-3.mol

Synonyms:(+/-)-3-<(4-Tertio-butyl dimethylsiloxy)-3-methoxybenzyl>butan-4-olide

Chemical Property of (+/-)-3-<(4-Tertio-butyl dimethylsiloxy)-3-methoxybenzyl>butan-4-olide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-3-<(4-Tertio-butyl dimethylsiloxy)-3-methoxybenzyl>butan-4-olide

There total 2 articles about (+/-)-3-<(4-Tertio-butyl dimethylsiloxy)-3-methoxybenzyl>butan-4-olide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(hydroxy-4 methoxy-3 benzyl)-4 dihydro-3H-furannone-2 (84755-40-8) + tert-butyldimethylsilyl chloride (18162-48-6) → (+/-)-3-<(4-Tertio-butyl dimethylsiloxy)-3-methoxybenzyl>butan-4-olide (140193-23-3)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 16h; Ambient temperature;

DOI:10.1016/S0040-4020(01)88129-1

Reference yield:

4-<<4-(benzyloxy)-3-methoxyphenyl>methyl>dihydro-2(3H)-furanone (92831-74-8) → (+/-)-3-<(4-Tertio-butyl dimethylsiloxy)-3-methoxybenzyl>butan-4-olide (140193-23-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C

2: imidazole / dimethylformamide / 20 °C

With 1H-imidazole; hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1039/b304411d

Reference yield: 96.0%

(+/-)-3-<(4-Tertio-butyl dimethylsiloxy)-3-methoxybenzyl>butan-4-olide (140193-23-3) → (+/-)-3-<α-Bromo-4-(tertio-butyl dimethylsiloxy)-3-methoxybenzyl>butan-4-olide (140193-24-4)

Guidance literature:

With N-Bromosuccinimide; Perbenzoic acid; In tetrachloromethane; for 1h; Heating;

DOI:10.1016/S0040-4020(01)88129-1

upstream raw materials:

(hydroxy-4 methoxy-3 benzyl)-4 dihydro-3H-furannone-2

tert-butyldimethylsilyl chloride

4-<<4-(benzyloxy)-3-methoxyphenyl>methyl>dihydro-2(3H)-furanone

Downstream raw materials:

(+/-)-3-<α-Bromo-4-(tertio-butyl dimethylsiloxy)-3-methoxybenzyl>butan-4-olide

C₃₄H₃₈⁽²⁾H₆O₇Si

dihydrovanillylsyringyl-2(3H)-furanone

4-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-benzyl]-3-(3,4,5-trimethoxy-benzyl)-dihydro-furan-2-one