(2S,3S,4R,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

Base Information

Chemical Name:(2S,3S,4R,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate
CAS No.:888330-57-2
Molecular Formula:C₁₉H₂₀N₂O₅
Molecular Weight:356.378
Hs Code.:

Synonyms:(2S,3S,4R,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,4R,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

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Technology Process of (2S,3S,4R,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

There total 6 articles about (2S,3S,4R,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 3179-10-0,5576-97-6
(E)-1-methoxy-4-(2-nitrovinyl)benzene

: 66646-88-6,120238-40-6,138495-05-3
(E)-N-benzylideneglycine methyl ester

: 888330-57-2
(2S,3S,4R,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

Guidance literature:: With tetrakis(acetonitrile)copper(I) perchlorate; 4 A molecular sieve; potassium tert-butylate; (S,S)-[2-(4'-isopropyloxazolin-2'-yl)ferrocenyl]diphenylphosphine; In tetrahydrofuran; at 0 ℃;
DOI:10.1002/anie.200503672

Reference yield: 64.0%

: 3179-10-0
1-methoxy-4-(2-nitro-vinyl)-benzene

: 66646-88-6
methyl 2-(benzylideneamino)acetate

: 888330-67-4
(2S,3R,4S,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

: 888330-57-2
(2S,3S,4R,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

Guidance literature:: With (R,Sp)-ThioClickFerrophos; silver(I) acetate; In 1,4-dioxane; at 20 ℃; for 10h; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2015.08.002

Reference yield: 63.0%

: 3179-10-0
1-methoxy-4-(2-nitro-vinyl)-benzene

: 66646-88-6
methyl 2-(benzylideneamino)acetate

: 888330-57-2
(2S,3S,4R,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

: (2S,3R,4S,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

Guidance literature:: With C₃₇H₃₃O₂P; copper(II) bis(trifluoromethanesulfonate); triethylamine; In toluene; at 20 - 30 ℃; for 17h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol4006618