5-phenyl-3-(4-methoxyphenyl)-2-methoxycarbonyl-4-nitro-1H-pyrrole

Base Information

• Chemical Name: 5-phenyl-3-(4-methoxyphenyl)-2-methoxycarbonyl-4-nitro-1H-pyrrole
• CAS No.: 943817-27-4
• Molecular Formula: C₁₉H₁₆N₂O₅
• Molecular Weight: 352.346
• Mol file: 943817-27-4.mol

Synonyms:5-phenyl-3-(4-methoxyphenyl)-2-methoxycarbonyl-4-nitro-1H-pyrrole

Chemical Property of 5-phenyl-3-(4-methoxyphenyl)-2-methoxycarbonyl-4-nitro-1H-pyrrole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-phenyl-3-(4-methoxyphenyl)-2-methoxycarbonyl-4-nitro-1H-pyrrole

There total 2 articles about 5-phenyl-3-(4-methoxyphenyl)-2-methoxycarbonyl-4-nitro-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-1-methoxy-4-(2-nitrovinyl)benzene (3179-10-0,5576-97-6) + (E)-N-benzylideneglycine methyl ester (66646-88-6,120238-40-6,138495-05-3) → methyl 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylate (943817-28-5) + 5-phenyl-3-(4-methoxyphenyl)-2-methoxycarbonyl-4-nitro-1H-pyrrole (943817-27-4)

Guidance literature:

(E)-1-methoxy-4-(2-nitrovinyl)benzene; (E)-N-benzylideneglycine methyl ester; With silver(I) acetate; triethylamine; In acetonitrile; at 20 ℃;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In xylene; at 100 ℃; for 0.75h; Microwave irradiation;

Reference yield:

(2S,3R,4S,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate (888330-67-4) + (2S,3S,4R,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate (888330-57-2) → methyl 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylate (943817-28-5) + 5-phenyl-3-(4-methoxyphenyl)-2-methoxycarbonyl-4-nitro-1H-pyrrole (943817-27-4)

Guidance literature:

With manganese(IV) oxide; In diethylene glycol dimethyl ether; for 48h; Heating / reflux;

Reference yield:

methyl 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylate (943817-28-5) + 5-phenyl-3-(4-methoxyphenyl)-2-methoxycarbonyl-4-nitro-1H-pyrrole (943817-27-4) → 5-phenyl-3-(4-methoxyphenyl)-4-nitro-1H-pyrrole-2-carboxylic acid (943817-25-2) + 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylic acid

Guidance literature:

methyl 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylate; 5-phenyl-3-(4-methoxyphenyl)-2-methoxycarbonyl-4-nitro-1H-pyrrole; With sodium hydroxide; ethanol; water; Heating / reflux;

With hydrogenchloride; water; In ethanol; at 0 ℃;

upstream raw materials:

(2S,3R,4S,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

(2S,3S,4R,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

(E)-1-methoxy-4-(2-nitrovinyl)benzene

(E)-N-benzylideneglycine methyl ester

Downstream raw materials:

5-phenyl-3-(4-methoxyphenyl)-4-nitro-1H-pyrrole-2-carboxylic acid