Technology Process of 2-(diphenylphosphino borane)-1-phenylethanol
There total 2 articles about 2-(diphenylphosphino borane)-1-phenylethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sec.-butyllithium;
In
tetrahydrofuran; pentane;
argon atmosphere; addn. of sec-butyllithium in pentane to soln. of Ph2MePBH3 in THF (-78°C), standig (-78°C, 2 h), addn. of PrCHO, stirring (0.5 h); treatment with aq. HCl, extn. (ether), drying of extracts (MgSO4), preparative TLC (silica gel);
DOI:10.1021/ja00169a036
- Guidance literature:
-
styrene oxide; potassium diphenylphosphine;
In
tetrahydrofuran;
at -78 - 0 ℃;
for 6.25h;
Inert atmosphere;
Schlenk technique;
borane-THF;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1.5h;
Inert atmosphere;
Schlenk technique;
With
water;
In
tetrahydrofuran;
regioselective reaction;
Inert atmosphere;
Schlenk technique;
DOI:10.1039/c4ra10432c
