α-(3,4-dimethoxyphenyl)-1,3-dihydro-α-<(4-methylphenyl)thio>-1,3-dioxo-2H-isoindole-2-heptanenitrile

Base Information

Chemical Name:α-(3,4-dimethoxyphenyl)-1,3-dihydro-α-<(4-methylphenyl)thio>-1,3-dioxo-2H-isoindole-2-heptanenitrile
CAS No.:167158-91-0
Molecular Formula:C₃₀H₃₀N₂O₄S
Molecular Weight:514.645
Hs Code.:

Synonyms:α-(3,4-dimethoxyphenyl)-1,3-dihydro-α-<(4-methylphenyl)thio>-1,3-dioxo-2H-isoindole-2-heptanenitrile

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Chemical Property of α-(3,4-dimethoxyphenyl)-1,3-dihydro-α-<(4-methylphenyl)thio>-1,3-dioxo-2H-isoindole-2-heptanenitrile

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Technology Process of α-(3,4-dimethoxyphenyl)-1,3-dihydro-α-<(4-methylphenyl)thio>-1,3-dioxo-2H-isoindole-2-heptanenitrile

There total 7 articles about α-(3,4-dimethoxyphenyl)-1,3-dihydro-α-<(4-methylphenyl)thio>-1,3-dioxo-2H-isoindole-2-heptanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1074-82-4
potassium phtalimide

: 167159-49-1
α-(5-iodopentyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

: 167158-91-0
α-(3,4-dimethoxyphenyl)-1,3-dihydro-α-<(4-methylphenyl)thio>-1,3-dioxo-2H-isoindole-2-heptanenitrile

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 2h;
DOI:10.1021/jm9804477

Reference yield:

: 67-56-1
methanol

aqueous potassium bicarbonate: aqueous potassium bicarbonate

: 1074-82-4
potassium phtalimide

: 167159-49-1
α-(5-iodopentyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

: 167158-91-0
α-(3,4-dimethoxyphenyl)-1,3-dihydro-α-<(4-methylphenyl)thio>-1,3-dioxo-2H-isoindole-2-heptanenitrile

Guidance literature:: In hexane; N,N-dimethyl-formamide;

Reference yield:

: 28750-77-8
α-chloro-3,4-dimetoxybenzeneacetonitrile

: 167158-91-0
α-(3,4-dimethoxyphenyl)-1,3-dihydro-α-<(4-methylphenyl)thio>-1,3-dioxo-2H-isoindole-2-heptanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / K₂CO₃ / acetonitrile / 12 h / 65 °C

2: 1.) NaH / 1.) DMSO, 25 deg C, 1.5 h, 2.) DMSO, 25 deg C, 3 h

3: 6.24 g / NaI / acetone / 12 h / Heating

4: 83 percent / dimethylformamide / 2 h / 100 °C

With sodium hydride; potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm9804477