(4-METHOXY-PHENYL)-CARBAMIC ACID ETHYL ESTER

Base Information

• Chemical Name: (4-METHOXY-PHENYL)-CARBAMIC ACID ETHYL ESTER
• CAS No.: 7451-55-0
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• Mol file: 7451-55-0.mol

Synonyms:Ethyl (4-methoxyphenyl)carbamate;Ethyl 4-methoxyphenylaminoformate;Ethyl N-(4-methoxyphenyl)carbamate;

Chemical Property of (4-METHOXY-PHENYL)-CARBAMIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.0175mmHg at 25°C
• Melting Point: -60 °C
• Refractive Index: 1.4420
• Boiling Point: 254.2 °C at 760 mmHg
• Flash Point: 107.5 °C
• Density: 1.152 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

ETHYL(4-METHOXY PHENYL)CARBAMATE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-METHOXY-PHENYL)-CARBAMIC ACID ETHYL ESTER

There total 29 articles about (4-METHOXY-PHENYL)-CARBAMIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

chloroformic acid ethyl ester (541-41-3) + 4-methoxy-aniline (104-94-9) → ethyl 4-methoxyphenylcarbamate (7451-55-0)

Guidance literature:

With TEA; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2006.09.103

Reference yield: 97.0%

diethyl 1-(4-methoxyphenyl)hydrazine-1,2-dicarboxylate → ethyl 4-methoxyphenylcarbamate (7451-55-0)

Guidance literature:

diethyl 1-(4-methoxyphenyl)hydrazine-1,2-dicarboxylate; With caesium carbonate; bromoacetic acid methyl ester; In acetonitrile; at 82 ℃;

With water; ammonium chloride; In acetonitrile;

DOI:10.1021/ol902313v

Reference yield: 94.0%

1-bromo-4-methoxy-benzene (104-92-7) + urethane (51-79-6) → ethyl 4-methoxyphenylcarbamate (7451-55-0)

Guidance literature:

With ?di-tert-butyl(2,2-diphenyl-1-methyl-1-cyclopropyl)phosphine; bis(η3-allyl-μ-chloropalladium(II)); sodium t-butanolate; In water; at 50 ℃; for 24h; Inert atmosphere; Green chemistry;

DOI:10.1039/c3gc42188k

upstream raw materials:

chloroformic acid ethyl ester

4-methoxy-aniline

ethanol

4-Methoxyphenyl isocyanate

Downstream raw materials:

2-(4-methoxy-phenyl)-4-phenyl-allophanic acid ethyl ester

2,4-bis-(4-methoxy-phenyl)-allophanic acid ethyl ester

N-(4-methoxyphenyl)piperidine-1-carboxamide

N,N'-p-anisyl<2.2>paracyclophane-4,5,12,13-tetracarboxylic acid bis-imide

Refernces

• 1、 Kumar, Arun,Kumar, Naveen,Sharma, Ritika,Bhargava, Gaurav,Mahajan, Dinesh. "Direct conversion of carboxylic acids to various nitrogen-containing compounds in the one-pot exploiting curtius rearrangement". . p. 11323 - 11334. Retrieved 2019/09/10.
• 2、 Ren, Long,Jiao, Ning. "PdCl2 catalyzed efficient assembly of organic azides, CO, and alcohols under mild conditions: A direct approach to synthesize carbamates". supporting information. p. 3706 - 3709. Retrieved 2014/04/03.