3-(1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile

Base Information

• Chemical Name: 3-(1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile
• CAS No.: 1253428-85-1
• Molecular Formula: C₁₉H₂₃N₃O
• Molecular Weight: 309.411
• Mol file: 1253428-85-1.mol

Synonyms:3-(1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile

Chemical Property of 3-(1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile

There total 9 articles about 3-(1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

4-tert-butylbenzyl cyanide (3288-99-1) + methyl 1-ethyl-3-methyl-1H-5-pyrazolecarboxylate (88398-73-6) → 3-(1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile (1253428-85-1)

Guidance literature:

4-tert-butylbenzyl cyanide; methyl 1-ethyl-3-methyl-1H-5-pyrazolecarboxylate; In 2-ethoxy-ethanol; n-heptane; for 1h; Inert atmosphere; Reflux;

With sodium methylate; In methanol; 2-ethoxy-ethanol; n-heptane; for 6h; Inert atmosphere; Reflux;

With hydrogenchloride; In water; pH=2 - 3;

Reference yield:

1-ethyl-3-methyl-5-pyrazolecarboxylic acid ethyl ester (50920-64-4) + 4-tert-butylbenzyl cyanide (3288-99-1) → 3-(1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile (1253428-85-1)

Guidance literature:

1-ethyl-3-methyl-5-pyrazolecarboxylic acid ethyl ester; 4-tert-butylbenzyl cyanide; In n-heptane; 2-methoxy-ethanol; for 1h; Reflux;

With sodium methylate; In n-heptane; 2-methoxy-ethanol; for 5h; Reflux;

DOI:10.1002/jhet.2682

Reference yield:

4-tert-butylbenzyl cyanide (3288-99-1) + (1-ethyl-3-methyl-1H-pyrazol-5-yl)(1H-pyrazol-1-yl)methanone → 3-(1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile (1253428-85-1)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 5 - 20 ℃;

DOI:10.1002/jhet.2682

upstream raw materials:

4-tert-butylbenzyl cyanide

methyl 1-ethyl-3-methyl-1H-5-pyrazolecarboxylate

3-methyl-1H-pyrazole-5-carboxylic acid methyl ester

methyl 2,4-dioxopentanoate

Downstream raw materials:

Z-2-(4-(tert-butyl)phenyl)-2-cyano-1-(1-ethyl-3-methyl-1H-5-pyrazolyl)vinyl pivalate

C₂₄H₃₁N₃O₂