N-(5-(5-(3,5-dichlorophenyl)-4,5-dihydro-5-trifluoromethyl-isoxazol-3-yl)-2-methyl-phenyl)-2-chloro-nicotinamide

Base Information

Chemical Name:N-(5-(5-(3,5-dichlorophenyl)-4,5-dihydro-5-trifluoromethyl-isoxazol-3-yl)-2-methyl-phenyl)-2-chloro-nicotinamide
CAS No.:1071927-34-8
Molecular Formula:C₂₃H₁₅Cl₃F₃N₃O₂
Molecular Weight:528.745
Hs Code.:

Synonyms:N-(5-(5-(3,5-dichlorophenyl)-4,5-dihydro-5-trifluoromethyl-isoxazol-3-yl)-2-methyl-phenyl)-2-chloro-nicotinamide

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Chemical Property of N-(5-(5-(3,5-dichlorophenyl)-4,5-dihydro-5-trifluoromethyl-isoxazol-3-yl)-2-methyl-phenyl)-2-chloro-nicotinamide

Chemical Property:

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Technology Process of N-(5-(5-(3,5-dichlorophenyl)-4,5-dihydro-5-trifluoromethyl-isoxazol-3-yl)-2-methyl-phenyl)-2-chloro-nicotinamide

There total 5 articles about N-(5-(5-(3,5-dichlorophenyl)-4,5-dihydro-5-trifluoromethyl-isoxazol-3-yl)-2-methyl-phenyl)-2-chloro-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 1071927-10-0
5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylaniline

: 1071927-34-8
N-(5-(5-(3,5-dichlorophenyl)-4,5-dihydro-5-trifluoromethyl-isoxazol-3-yl)-2-methyl-phenyl)-2-chloro-nicotinamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 31680-07-6
4-methyl-3-nitrobenzaldehyde

: 1071927-34-8
N-(5-(5-(3,5-dichlorophenyl)-4,5-dihydro-5-trifluoromethyl-isoxazol-3-yl)-2-methyl-phenyl)-2-chloro-nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 1 h / 20 °C

2: N-chloro-succinimide / N,N-dimethyl-formamide / 50 °C

3: triethylamine / N,N-dimethyl-formamide / 6 h / 20 °C

4: acetic acid / iron / ethanol; water / 1.25 h / 75 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; iron; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: C₈H₇ClN₂O₃

: 1071927-34-8
N-(5-(5-(3,5-dichlorophenyl)-4,5-dihydro-5-trifluoromethyl-isoxazol-3-yl)-2-methyl-phenyl)-2-chloro-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 6 h / 20 °C

2: acetic acid / iron / ethanol; water / 1.25 h / 75 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

With acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; iron; In ethanol; water; N,N-dimethyl-formamide;