3-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanoic acid

Base Information

• Chemical Name: 3-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanoic acid
• CAS No.: 307299-14-5
• Molecular Formula: C₁₅H₁₀N₂O₆
• Molecular Weight: 314.254
• Mol file: 307299-14-5.mol

Synonyms:3-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanoic acid

Chemical Property of 3-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanoic acid

Chemical Property:

• Melting Point: 198-200 °C(Solv: ethanol (64-17-5))
• Boiling Point: 607.2±45.0 °C(Predicted)
• PKA: 4.22±0.10(Predicted)
• Density: 1.593±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanoic acid

There total 4 articles about 3-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-nitronaphthalic-1,8-anhydride (6642-29-1) + 3-amino propanoic acid (107-95-9) → 3-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanoic acid (307299-14-5)

Guidance literature:

In ethanol; for 4h; Reflux;

DOI:10.1016/j.jphotochem.2020.112878

Reference yield:

2-nitro-1,8-naphthalic anhydride (34087-02-0) + 3-amino propanoic acid (107-95-9) → 3-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanoic acid (307299-14-5)

Guidance literature:

In chloroform;

Reference yield:

acenaphthene (83-32-9) → 3-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanoic acid (307299-14-5)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid; acetic acid / 0 °C

2: acetic acid; sodium dichromate / 100 °C

3: potassium carbonate / acetonitrile / 5 h / 85 °C

With sodium dichromate; nitric acid; potassium carbonate; acetic acid; In acetonitrile;

DOI:10.1016/j.bioorg.2020.104011

upstream raw materials:

4-nitronaphthalic-1,8-anhydride

3-amino propanoic acid

2-nitro-1,8-naphthalic anhydride

acenaphthene

Downstream raw materials:

C₄₅H₄₈N₄O₇PS₂⁽¹⁺⁾

C₃₅H₃₁N₃O₃P⁽¹⁺⁾

C₄₀H₃₉N₃O₆PS₂⁽¹⁺⁾