6-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-pyridine-2-carboximidic acid methyl ester

Base Information

Chemical Name:6-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-pyridine-2-carboximidic acid methyl ester
CAS No.:204917-71-5
Molecular Formula:C₁₇H₂₆N₂O
Molecular Weight:274.406
Hs Code.:

Synonyms:6-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-pyridine-2-carboximidic acid methyl ester

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Chemical Property of 6-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-pyridine-2-carboximidic acid methyl ester

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Technology Process of 6-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-pyridine-2-carboximidic acid methyl ester

There total 5 articles about 6-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-pyridine-2-carboximidic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 67-56-1
methanol

: 204917-69-1
(-)-2-cyano-6-L-menthylpyridine

: 204917-71-5
6-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-pyridine-2-carboximidic acid methyl ester

Guidance literature:: With sodium methylate; for 72h; Ambient temperature;
DOI:10.1016/S0957-4166(97)00619-8

Reference yield:

: 109-04-6
2-bromo-pyridine

: 204917-71-5
6-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-pyridine-2-carboximidic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Mg, 1,2-dibromoethane, 2.) Pd(dppf)Cl₂ / 1.) THF, 50 deg C, 16 h, 2.) THF, 0 deg C, 48 h

2: 89 percent / m-cpba / CH₂Cl₂ / 72 h / Ambient temperature

3: 78 percent / dimethylcarbamoyl chloride / CH₂Cl₂ / 72 h

4: 98 percent / NaOMe / 72 h / Ambient temperature

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium methylate; magnesium; ethylene dibromide; 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride; In dichloromethane;
DOI:10.1016/S0957-4166(97)00619-8

Reference yield:

: 16052-42-9
(1R,2S,5R)-menthyl chloride

: 204917-71-5
6-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-pyridine-2-carboximidic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Mg, 1,2-dibromoethane, 2.) Pd(dppf)Cl₂ / 1.) THF, 50 deg C, 16 h, 2.) THF, 0 deg C, 48 h

2: 89 percent / m-cpba / CH₂Cl₂ / 72 h / Ambient temperature

3: 78 percent / dimethylcarbamoyl chloride / CH₂Cl₂ / 72 h

4: 98 percent / NaOMe / 72 h / Ambient temperature

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium methylate; magnesium; ethylene dibromide; 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride; In dichloromethane;
DOI:10.1016/S0957-4166(97)00619-8