3-(4-{2-benzyloxy-5-[2-(methoxymethylcarbamoyl)ethyl]phenoxy}-3-methoxyphenyl)-N-methoxy-N-methylpropionamide

Base Information

Chemical Name:3-(4-{2-benzyloxy-5-[2-(methoxymethylcarbamoyl)ethyl]phenoxy}-3-methoxyphenyl)-N-methoxy-N-methylpropionamide
CAS No.:478706-20-6
Molecular Formula:C₃₀H₃₆N₂O₇
Molecular Weight:536.625
Hs Code.:

Synonyms:3-(4-{2-benzyloxy-5-[2-(methoxymethylcarbamoyl)ethyl]phenoxy}-3-methoxyphenyl)-N-methoxy-N-methylpropionamide

Suppliers and Price of 3-(4-{2-benzyloxy-5-[2-(methoxymethylcarbamoyl)ethyl]phenoxy}-3-methoxyphenyl)-N-methoxy-N-methylpropionamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(4-{2-benzyloxy-5-[2-(methoxymethylcarbamoyl)ethyl]phenoxy}-3-methoxyphenyl)-N-methoxy-N-methylpropionamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(4-{2-benzyloxy-5-[2-(methoxymethylcarbamoyl)ethyl]phenoxy}-3-methoxyphenyl)-N-methoxy-N-methylpropionamide

There total 6 articles about 3-(4-{2-benzyloxy-5-[2-(methoxymethylcarbamoyl)ethyl]phenoxy}-3-methoxyphenyl)-N-methoxy-N-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 478706-19-3
3-{4-[2-benzyloxy-5-(2-carboxylethyl)phenoxy]-3-methoxyphenyl}propionic acid

: 478706-20-6
3-(4-{2-benzyloxy-5-[2-(methoxymethylcarbamoyl)ethyl]phenoxy}-3-methoxyphenyl)-N-methoxy-N-methylpropionamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/S0040-4020(02)00915-8

Reference yield:

: 250284-66-3
ethyl 3-(3-bromo-4-hydroxyphenyl)propanoate

: 478706-20-6
3-(4-{2-benzyloxy-5-[2-(methoxymethylcarbamoyl)ethyl]phenoxy}-3-methoxyphenyl)-N-methoxy-N-methylpropionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / K₂CO₃ / ethanol / Heating

2: 78 percent / (CuOTf)2PhMe; Cs₂CO₃; pyridine / 110 °C

3: 95 percent / aq. NaOH / tetrahydrofuran; methanol / 20 °C

4: 94 percent / HBTU; diisopropyl ethyl amine / CH₂Cl₂

With pyridine; sodium hydroxide; copper(I) trifluoromethanesolfonate toluene complex; potassium carbonate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.12.001

Reference yield:

: 478706-17-1
ethyl 3-(4-benzyloxy-3-bromophenyl)propionate

: 478706-20-6
3-(4-{2-benzyloxy-5-[2-(methoxymethylcarbamoyl)ethyl]phenoxy}-3-methoxyphenyl)-N-methoxy-N-methylpropionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / (CuOTf)2PhMe; Cs₂CO₃; pyridine / 110 °C

2: 95 percent / aq. NaOH / tetrahydrofuran; methanol / 20 °C

3: 94 percent / HBTU; diisopropyl ethyl amine / CH₂Cl₂

With pyridine; sodium hydroxide; copper(I) trifluoromethanesolfonate toluene complex; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.12.001