N-methyl-3-(1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide

Base Information

Chemical Name:N-methyl-3-(1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide
CAS No.:1333147-01-5
Molecular Formula:C₂₆H₂₁F₃N₄O₃
Molecular Weight:494.473
Hs Code.:

Synonyms:N-methyl-3-(1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide

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Chemical Property of N-methyl-3-(1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide

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Technology Process of N-methyl-3-(1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide

There total 5 articles about N-methyl-3-(1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1333146-99-8
ethyl 3-(1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanoate

: 74-89-5
methylamine

: 1333147-01-5
N-methyl-3-(1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide

Guidance literature:: In ethanol; at 120 ℃; for 16h; Sealed tube;
DOI:10.1021/jm2007744

Reference yield:

: 1333146-98-7
(Z)-ethyl 4-hydroxy-6-oxo-6-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)hex-4-enoate

: 1333147-01-5
N-methyl-3-(1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / ethanol / 0.17 h / Microwave irradiation

2: ethanol / 16 h / 120 °C / Sealed tube

With toluene-4-sulfonic acid; In ethanol;
DOI:10.1021/jm2007744

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1333147-01-5
N-methyl-3-(1-(4-nitrophenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / water / 2 h / 60 °C / Inert atmosphere

2.1: magnesium bromide ethyl etherate / dichloromethane / 0.17 h / Inert atmosphere

2.2: 16 h / Inert atmosphere

3.1: toluene-4-sulfonic acid / ethanol / 0.17 h / Microwave irradiation

4.1: ethanol / 16 h / 120 °C / Sealed tube

With tetrabutylammomium bromide; palladium diacetate; potassium carbonate; toluene-4-sulfonic acid; magnesium bromide ethyl etherate; In ethanol; dichloromethane; water;
DOI:10.1021/jm2007744