3-Cyclopentyl-1,6-dimethyl-4-(3-trifluoromethyl-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester; hydrochloride

Base Information

Chemical Name:3-Cyclopentyl-1,6-dimethyl-4-(3-trifluoromethyl-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester; hydrochloride
CAS No.:118432-10-3
Molecular Formula:C₂₂H₂₄F₃N₃O₂*ClH
Molecular Weight:455.908
Hs Code.:

3-Cyclopentyl-1,6-dimethyl-4-(3-trifluoromethyl-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester; hydrochloride

Synonyms:3-Cyclopentyl-1,6-dimethyl-4-(3-trifluoromethyl-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester; hydrochloride

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Chemical Property of 3-Cyclopentyl-1,6-dimethyl-4-(3-trifluoromethyl-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester; hydrochloride

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Technology Process of 3-Cyclopentyl-1,6-dimethyl-4-(3-trifluoromethyl-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester; hydrochloride

There total 4 articles about 3-Cyclopentyl-1,6-dimethyl-4-(3-trifluoromethyl-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 39561-94-9
methyl 2-(2-trifluoromethylphenylmethylene)acetoacetate

: 92406-39-8
5-amino-3-cyclopentyl-1-methylpyrazole

: 118432-10-3
3-Cyclopentyl-1,6-dimethyl-4-(3-trifluoromethyl-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester; hydrochloride

Guidance literature:: In tert-butyl alcohol; at 80 ℃; for 24h;
DOI:10.1248/cpb.35.3235

Reference yield:

: 95882-33-0
3-cyclopentyl-3-oxopropanenitrile

: 118432-10-3
3-Cyclopentyl-1,6-dimethyl-4-(3-trifluoromethyl-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 74.4 percent / ethanol / 5 h / Heating

2: 88 percent / 2-methyl-propan-2-ol / 24 h / 80 °C

In ethanol; tert-butyl alcohol;
DOI:10.1248/cpb.35.3235

Reference yield:

: 447-61-0
2-Trifluoromethylbenzaldehyde

: 118432-10-3
3-Cyclopentyl-1,6-dimethyl-4-(3-trifluoromethyl-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / AcOH, piperidine / benzene / 24 h / 30 - 45 °C

2: 88 percent / 2-methyl-propan-2-ol / 24 h / 80 °C

With piperidine; acetic acid; In tert-butyl alcohol; benzene;
DOI:10.1248/cpb.35.3235