(2R,4S,6R,8S,10S)-8-(2-Benzyloxy-ethyl)-10-benzyloxymethoxy-4-methyl-2-vinyl-1,7-dioxa-spiro[5.5]undecan-4-ol

Base Information

Chemical Name:(2R,4S,6R,8S,10S)-8-(2-Benzyloxy-ethyl)-10-benzyloxymethoxy-4-methyl-2-vinyl-1,7-dioxa-spiro[5.5]undecan-4-ol
CAS No.:881667-68-1
Molecular Formula:C₂₉H₃₈O₆
Molecular Weight:482.617
Hs Code.:

Synonyms:(2R,4S,6R,8S,10S)-8-(2-Benzyloxy-ethyl)-10-benzyloxymethoxy-4-methyl-2-vinyl-1,7-dioxa-spiro[5.5]undecan-4-ol

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Chemical Property of (2R,4S,6R,8S,10S)-8-(2-Benzyloxy-ethyl)-10-benzyloxymethoxy-4-methyl-2-vinyl-1,7-dioxa-spiro[5.5]undecan-4-ol

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Technology Process of (2R,4S,6R,8S,10S)-8-(2-Benzyloxy-ethyl)-10-benzyloxymethoxy-4-methyl-2-vinyl-1,7-dioxa-spiro[5.5]undecan-4-ol

There total 8 articles about (2R,4S,6R,8S,10S)-8-(2-Benzyloxy-ethyl)-10-benzyloxymethoxy-4-methyl-2-vinyl-1,7-dioxa-spiro[5.5]undecan-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 881667-64-7
2-((2S,4S)-6-Benzyloxy-2-benzyloxymethoxy-4-hydroxy-hexyl)-pyran-4-one

: 881667-68-1
(2R,4S,6R,8S,10S)-8-(2-Benzyloxy-ethyl)-10-benzyloxymethoxy-4-methyl-2-vinyl-1,7-dioxa-spiro[5.5]undecan-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 64 percent / trifluoroacetic acid / benzene / 72 h / 20 °C

2.1: tetrakis(copper(I) iodide-tributylphosphine) complex / diethyl ether / 1 h / -55 °C

2.2: diethyl ether / -78 °C

3.1: 22 mg / tetrahydrofuran / 4 h / -78 °C

With [(triphenylphosphine)CuI]4; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; benzene; 3.1: Grignard reaction;
DOI:10.1021/ol0601601

Reference yield:

: 881667-65-8
(6R,8S,10S)-8-(2-Benzyloxy-ethyl)-10-benzyloxymethoxy-1,7-dioxa-spiro[5.5]undec-2-en-4-one

: 881667-68-1
(2R,4S,6R,8S,10S)-8-(2-Benzyloxy-ethyl)-10-benzyloxymethoxy-4-methyl-2-vinyl-1,7-dioxa-spiro[5.5]undecan-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(copper(I) iodide-tributylphosphine) complex / diethyl ether / 1 h / -55 °C

1.2: diethyl ether / -78 °C

2.1: 22 mg / tetrahydrofuran / 4 h / -78 °C

With [(triphenylphosphine)CuI]4; In tetrahydrofuran; diethyl ether; 2.1: Grignard reaction;
DOI:10.1021/ol0601601

Reference yield:

: 881667-67-0
6-[(2S,4S)-6-Benzyloxy-2-hydroxy-4-(4-methoxy-benzyloxy)-hexyl]-2,2-dimethyl-[1,3]dioxin-4-one

: 881667-68-1
(2R,4S,6R,8S,10S)-8-(2-Benzyloxy-ethyl)-10-benzyloxymethoxy-4-methyl-2-vinyl-1,7-dioxa-spiro[5.5]undecan-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 94 percent / N,N-diisopropylethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / Heating

2.1: toluene / 3.5 h / 110 °C

3.1: 1.24 g / p-toluenesulfonic acid / tetrahydrofuran / 2 h / Heating

4.1: 95 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; buffer / CH₂Cl₂ / 1 h / pH 7

5.1: 64 percent / trifluoroacetic acid / benzene / 72 h / 20 °C

6.1: tetrakis(copper(I) iodide-tributylphosphine) complex / diethyl ether / 1 h / -55 °C

6.2: diethyl ether / -78 °C

7.1: 22 mg / tetrahydrofuran / 4 h / -78 °C

With dmap; [(triphenylphosphine)CuI]4; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; benzene; 2.1: Diels-Alder reaction / 7.1: Grignard reaction;
DOI:10.1021/ol0601601