58511-69-6Relevant academic research and scientific papers
An improved synthesis of psammaplin A
Godert, Amy M.,Angelino, Norman,Woloszynska-Read, Anna,Morey, Shannon R.,James, Smitha R.,Karpf, Adam R.,Sufrin, Janice R.
, p. 3330 - 3333 (2008/12/22)
The marine natural product, psammaplin A, was first isolated from the Psammaplinaplysilla sponge in 1987. Since that time, psammaplin A has shown a wide spectrum of biological activities that include enzyme inhibitory activities resulting in antibacterial and antitumor effects. An improved synthesis of psammaplin A has been developed, making the compound more easily accessible for further biological evaluations. In this context, we find that psammaplin A is an effective DNA methyltransferase inhibitor in vitro but fails to alter genomic DNA methylation levels in treated human cancer cells.
Efficient total synthesis of bastadin 6, an anti-angiogenic brominated tyrosine-derived metabolite from marine sponge
Kotoku, Naoyuki,Tsujita, Hiroaki,Hiramatsu, Atsushi,Mori, Chinatsu,Koizumi, Noriko,Kobayashi, Motomasa
, p. 7211 - 7218 (2007/10/03)
An efficient total synthesis of bastadin 6 (1), a cyclic tetramer of brominated tyrosine derivatives from the marine sponge, Ianthella basta, with selective anti-angiogenic activity, was accomplished. We developed a novel Ce(IV)-mediated oxidative couplin
