(3R,5S,8S)-8-butyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-7,10-dioxo-22-phenyl-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1-3,6-.0-20,24-]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxamide

Base Information

• Chemical Name: (3R,5S,8S)-8-butyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-7,10-dioxo-22-phenyl-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1-3,6-.0-20,24-]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxamide
• CAS No.: 914823-96-4
• Molecular Formula: C₄₁H₄₉N₅O₈S
• Molecular Weight: 771.935

Synonyms:(3R,5S,8S)-8-butyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-7,10-dioxo-22-phenyl-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1-3,6-.0-20,24-]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxamide

Chemical Property of (3R,5S,8S)-8-butyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-7,10-dioxo-22-phenyl-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1-3,6-.0-20,24-]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxamide

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Technology Process of (3R,5S,8S)-8-butyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-7,10-dioxo-22-phenyl-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1-3,6-.0-20,24-]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxamide

There total 2 articles about (3R,5S,8S)-8-butyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-7,10-dioxo-22-phenyl-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1-3,6-.0-20,24-]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

cyclopropanesulphonamide (154350-29-5) → (3R,5S,8S)-8-butyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-7,10-dioxo-22-phenyl-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1-3,6-.0-20,24-]hexacosa-1(23),17,19,21,24-pentaene-5-carboxamide (914823-96-4)

Guidance literature:

(1R,2S)-1-({[(3R,5S,8S)-8-butyl-7,10-dioxo-22-phenyl-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1-3,6-.0-20,24-]hexacosa-1⁽²³⁾,17,19,21,24-pentaen-5-yl]carbonyl}amino)-2-vinylcyclopropanecarboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 40 ℃; for 1h;

cyclopropanesulphonamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; for 1h;

Reference yield:

(1R,2S)-1-amino-N-(cyclopropylsulfonyl)-2-vinylcyclopropanecarboxamide hydrochloride (630421-49-7) + C32H37N3O6 → (3R,5S,8S)-8-butyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-7,10-dioxo-22-phenyl-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1-3,6-.0-20,24-]hexacosa-1(23),17,19,21,24-pentaene-5-carboxamide (914823-96-4)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 2h;

DOI:10.1021/ja711120r

Reference yield:

(3R,5S,8S)-8-butyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-7,10-dioxo-22-phenyl-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1-3,6-.0-20,24-]hexacosa-1(23),17,19,21,24-pentaene-5-carboxamide (914823-96-4) → (2R,4S,7S)-7-butyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-ethylcyclopropyl)-6,9-dioxo-20-phenyl-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-ethanediylidene-2,5-methanopyrido[4,3-κ][1,10,3,6]dioxadiazacyclononadecine-4-carboxamide

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 3h;

upstream raw materials:

cyclopropanesulphonamide

(1R,2S)-1-amino-N-(cyclopropylsulfonyl)-2-vinylcyclopropanecarboxamide hydrochloride

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