cloxazolam

Base Information

• Chemical Name: cloxazolam
• CAS No.: 158251-57-1
• Molecular Formula: C₁₇H₁₄Cl₂N₂O₂
• Molecular Weight: 349.216
• Mol file: 158251-57-1.mol

Synonyms:Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one, 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-, (S)-

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Chemical Property of cloxazolam

Chemical Property:

• PSA: 41.57000
• LogP: 3.55470

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cloxazolam

There total 5 articles about cloxazolam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxirane (75-21-8,99932-75-9) + delorazepam (2894-67-9) → cloxazolam (24166-13-0,158251-57-1)

Guidance literature:

aluminium trichloride; In benzene;

Reference yield:

N-(2-hydroxy-ethyl)-glycine 4-chloro-2-(2-chloro-benzoyl)-anilide (24234-92-2) → cloxazolam (24166-13-0,158251-57-1)

Guidance literature:

With acetic acid; In ethanol; Heating;

DOI:10.1021/jm00288a015

Reference yield:

2-(2-bromo-acetylamino)-5,2'-dichloro-benzophenone (5504-92-7) → cloxazolam (24166-13-0,158251-57-1)

Guidance literature:

Multi-step reaction with 2 steps

2: AcOH / ethanol / Heating

With acetic acid; In ethanol;

DOI:10.1021/jm00288a015

upstream raw materials:

N-(2-hydroxy-ethyl)-glycine 4-chloro-2-(2-chloro-benzoyl)-anilide

2-(2-bromo-acetylamino)-5,2'-dichloro-benzophenone

oxirane

delorazepam

Downstream raw materials:

10-chloro-11b-(2-chloro-phenyl)-7-methyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one

10-chloro-11b-(2-chloro-phenyl)-7-ethyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one

N-(2-hydroxy-ethyl)-glycine 4-chloro-2-(2-chloro-benzoyl)-anilide